tet(r)

tetracycline repressor

Validation StatusSupported

Overview

Mechanism: confers resistance to tetracyclines
Validation Method: experimental validation
Drug Classes: Tetracycline, Doxycycline, Minocycline
Organisms: Escherichia coli, Salmonella, Salmonella enterica, Mannheimia haemolytica, Pasteurella multocida, Haemophilus somnus, Salmonella enterica subsp. enterica serovar Typhi, Acinetobacter baumannii, Enterococcus faecalis, Acinetobacter baumannii AB329, Klebsiella pneumoniae
Geographic Location: Alberta|North America, Australia, India, Italy, Lebanon +6 more
Papers: 14
Databases: Reslit

Papers14

Genetic mechanisms of antimicrobial resistance identified in Salmonella enterica, Escherichia coli, and Enteroccocus spp. isolated from U.S. food animals.

PMID 23734150 · 2013

The study identifies various AMR genes in Salmonella enterica, Escherichia coli, and Enterococcus spp. isolated from U.S. food animals, including aac(3'), aac(6'), aadA, aadA1, aadA2, aadA12, aphAI, aph(3')-Ii-iv, strA, strB, bla CMY-2, bla TEM-1, bla PSE-1, floR, cmlA, cat1, cat2, sul1, sul2, dfr1, dfrA10, tet(A), tet(B), tet(C), tet(D), tet(G), and tetR.

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Encodes: tetracycline repressor
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Escherichia coli
• Salmonella
Geographic Location: United States|U.S.|France|Korea
Validation Method: experimental validation

Carriage of Extended-Spectrum Beta-Lactamase-Plasmids Does Not Reduce Fitness but Enhances Virulence in Some Strains of Pandemic E. coli Lineages.

PMID 27014251 · 2016

The study found that ESBL-plasmid carriage does not reduce fitness but enhances virulence in some strains of pandemic E. coli lineages. It identified several AMR genes on the ESBL-plasmids, including beta-lactamases (blaCTX-M-15, blaCTX-M-27, blaCTX-M-14), tetracycline resistance genes (tetA, tetR), aminoglycoside resistance genes (aadA, aac(6')-Ib-cr), chloramphenicol resistance gene (catB4), sulfonamide resistance gene (sul2), streptomycin resistance genes (strA, strB), dihydrofolate reductase genes (dhfrVII, dfrA17), and aminoglycoside phosphotransferase gene (aph(3')-Ia). Non-antibiotic resistance genes such as finO, traT, icc, yfaX, yihA, and hha were also identified.

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Encodes: tetracycline_efflux_protein
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Escherichia coli
Validation Method: plasmid_profile_analysis
Sequence Accession: ERR163891|ERR163889|ERR163879|ERR163883|ERR163880|ERR163881|ERR264283

Whole-Genome Sequencing of Drug-Resistant Salmonella enterica Isolates from Dairy Cattle and Humans in New York and Washington States Reveals Source and Geographic Associations.

PMID 28389536 · 2017

The study identified several AMR genes and mutations in Salmonella enterica isolates from dairy cattle and humans in New York and Washington States, highlighting the role of geographic and source-specific factors in AMR dissemination.

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Encodes: tetracycline efflux pump
Source Database: Reslit
Mechanism: confers resistance to tetracyclines
Confers Resistance To: Tetracycline
Organisms Tested In: • Salmonella enterica
Geographic Location: New York|Washington
Validation Method: nucleotide BLAST and ARG-ANNOT
Sequence Accession: NCBI BioProject PRJNA353421

Genomic Characterization of MDR Escherichia coli Harboring bla(OXA-48) on the IncL/M-type Plasmid Isolated from Blood Stream Infection.

PMID 30050923 · 2018

The study identified multiple AMR genes, including blaOXA-48, blaCTX-M-3, blaTEM-1B, blaOXA-1, aac(3)-IId, tet(A), tet(R), and blaCMY-70, in an MDR E. coli isolate. It also detected mutations in gyrA (S83L, D87N) and parC (S80I) contributing to fluoroquinolone resistance.

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Encodes: tetracycline efflux pump
Source Database: Reslit
Mechanism: efflux
Confers Resistance To: Tetracycline
Organisms Tested In: • Escherichia coli
Geographic Location: Lebanon
Validation Method: genomic analysis
Sequence Accession: LJOJ00000000

Emergence of carbapenemase-producing Enterobacteriaceae in Malawi.

PMID 31899349 · 2020

The study reports the detection of an NDM-5 producing E. coli in Malawi, highlighting the emergence of carbapenem-resistant Enterobacteriaceae in the region.

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Source Database: Reslit
Mechanism: tetracycline resistance
Confers Resistance To: Tetracycline
Organisms Tested In: • Escherichia coli
Geographic Location: Malawi
Validation Method: whole genome sequencing
Sequence Accession: ERS2493547

Antimicrobial Resistance in Members of the Bacterial Bovine Respiratory Disease Complex Isolated from Lung Tissue of Cattle Mortalities Managed with or without the Use of Antimicrobials.

PMID 32093326 · 2020

The study identified several AMR genes, including aadA31, bla ROB-1, floR, mph(E), msr(E), and tet(H), in bovine respiratory disease organisms, highlighting the impact of antimicrobial use on AMR development.

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Encodes: tetracycline repressor
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Mannheimia haemolytica
• Pasteurella multocida
• Haemophilus somnus
Geographic Location: Alberta|North America
Validation Method: PCR and WGS
Sequence Accession: PRJNA313047

Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.

PMID 32427945 · 2020

The study identified several AMR genes and mutations in Salmonella Typhi isolates, including beta-lactamases (blaTEM-1B, blaTEM-116), chloramphenicol resistance gene (catA1), trimethoprim resistance genes (dfrA7, dfrA15), sulfamethoxazole resistance genes (sul1, sul2), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE genes.

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Typhi
Geographic Location: India
Validation Method: WGS
Sequence Accession: NCBI BioProject: PRJNA544013

Subtypes, resistance and virulence platforms in extended-drug resistant Acinetobacter baumannii Romanian isolates.

PMID 34168184 · 2021

The study identifies several AMR genes including bla OXA-23, bla OXA-24, bla OXA-51, and various aminoglycoside, sulfonamide, tetracycline, and macrolide resistance genes in XDR A. baumannii isolates from Romania.

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Encodes: Tetracycline resistance
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Romania|Spain
Validation Method: WGS
Sequence Accession: CP031382.1|NZ_KX230793.1|NZ_MT230226.1|NZ_CP043569.1|SRX4094320|SRX4094321|SRX4094322|SRX4094323|SAMN14525745|SAMN14525746|SAMN14525747

Diverse Bacterial Resistance Genes Detected in Fecal Samples From Clinically Healthy Women and Infants in Australia-A Descriptive Pilot Study.

PMID 34603219 · 2021

The study identified 64 unique antimicrobial resistance genes (ARGs) in fecal samples from clinically healthy individuals in Australia, with a focus on tetracycline, beta-lactam, and MLS B resistance genes.

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Encodes: Tetracycline resistance ribosomal protection protein
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Enterococcus faecalis
Geographic Location: Australia
Validation Method: Metagenomic analysis
Sequence Accession: PRJEB36405

A Metagenomic Approach for Characterizing Antibiotic Resistance Genes in Specific Bacterial Populations: Demonstration with Escherichia coli in Cattle Manure.

PMID 35285243 · 2022

The study identified multiple antibiotic resistance genes in E. coli populations from cattle manure, including genes conferring resistance to tetracycline, aminoglycosides, chloramphenicol, sulfonamides, and glycopeptides. These genes were found to be associated with mobile genetic elements, highlighting the potential for horizontal gene transfer.

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Encodes: tetracycline resistance protein
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Escherichia coli
Geographic Location: United States
Validation Method: metagenomic sequencing and bioinformatic analysis
Sequence Accession: SRR11391796|SRR11391797|SRR11391798|SRR11391799|SRR11391800|SRR11391801

Genomic Characterization of an O101:H9-ST167 NDM-5-Producing Escherichia coli Strain from a Kitten in Italy.

PMID 35665628 · 2022

The study characterizes an NDM-5-producing Escherichia coli ST167 strain from a kitten in Italy, highlighting the presence of multiple AMR genes including blaNDM-5, bla_ble, blaAmpH, blaAmpC1, and others, along with mutations in gyrA, parC, and parE contributing to fluoroquinolone resistance.

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Escherichia coli
Geographic Location: Italy
Validation Method: genomic sequencing and antimicrobial susceptibility testing
Sequence Accession: PRJNA816063|SAMN26656496

Insights into mobile genetic elements and the role of conjugative plasmid in transferring aminoglycoside resistance in extensively drug-resistant Acinetobacter baumannii AB329.

PMID 35855908 · 2022

The study identified several AMR genes in the extensively drug-resistant Acinetobacter baumannii AB329, including beta-lactamases (blaOXA-51, blaADC-25, blaOXA-23, blaTEM-1D), aminoglycoside resistance genes (aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, armA), tetracycline resistance genes (tet(B), tet(R)), and macrolide resistance genes (mph(E), msr(E)). Additionally, the aminoglycoside resistance gene aph(3')-VIa was found on the conjugative plasmid pAB329b, which was shown to transfer resistance to sodium azide-resistant A. baumannii.

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Encodes: tetracycline ribosomal protection protein
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Acinetobacter baumannii AB329
Geographic Location: Thailand
Validation Method: genome sequencing
Sequence Accession: CP091452|CP091453|CP091454

Effects of Nutrient Level and Growth Rate on the Conjugation Process That Transfers Mobile Antibiotic Resistance Genes in Continuous Cultures.

PMID 36094214 · 2022

The study identifies the tetracycline resistance genes tet(A) and tet(R) transferred via plasmids from wastewater treatment plant effluent to river bacteria, demonstrating increased resistance levels in transconjugants.

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Encodes: tetracycline resistance protein
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Escherichia coli
Validation Method: whole-genome sequencing and MIC testing
Sequence Accession: PRJNA750500

Multidrug-resistant ST11-KL64 hypervirulent Klebsiella pneumoniae with multiple bla- genes isolated from children's blood.

PMID 39834491 · 2024

Gene Information

Gene Name: tet(r)
Allele: tet(R)
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: TetracyclineDoxycyclineMinocycline
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: genomic analysis

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tet(r)

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