tetA

tetracycline efflux protein

Validation StatusSupported

Overview

Mechanism: efflux
Validation Method: cloning in E. coli + MIC testing
Drug Classes: tetracycline, oxytetracycline, minocycline
Organisms: Vibrio harveyi, Escherichia coli, Salmonella enterica serovar Typhimurium, Vibrio cholerae O1
Geographic Location: Italy, Laos, Toronto, Canada|Vancouver, Canada|India
Papers: 5
Databases: Reslit

Papers5

Genetic determinants of tetracycline resistance in Vibrio harveyi.

PMID 11897587 · 2002

Two tetracycline resistance determinants, tetA and tet35, were identified in Vibrio harveyi M3.4L. Both genes conferred resistance to tetracycline, oxytetracycline, and minocycline when cloned in E. coli.

Gene Information

Gene Name: tetA
Allele: tetA
Encodes: tetracycline efflux protein
Source Database: Reslit
Mechanism: efflux
Confers Resistance To: tetracyclineoxytetracyclineminocycline
Organisms Tested In: • Vibrio harveyi
• Escherichia coli
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AF353562

Antibiotic Resistance Genes and Salmonella Genomic Island 1 in Salmonella enterica Serovar Typhimurium Isolated in Italy.

PMID 12183234 · 2002

The study identifies antibiotic resistance genes and the presence of Salmonella Genomic Island 1 (SGI1) in multidrug-resistant Salmonella enterica serovar Typhimurium isolates from Italy. Key resistance genes include aadA2, pse-1, floR, tetA, and tetR, which contribute to resistance against various antibiotics.

Gene Information

Gene Name: tetA
Allele: tetA
Encodes: tetracycline resistance
Source Database: Reslit
Mechanism: genomic island gene
Confers Resistance To: tetracycline
Organisms Tested In: • Salmonella enterica serovar Typhimurium
Geographic Location: Italy
Validation Method: Southern blot hybridization and PCR
Sequence Accession: AF261825

Antibiotic Resistance Conferred by a Class I Integron and SXT Constin in Vibrio cholerae O1 Strains Isolated in Laos.

PMID 15215082 · 2004

The study identifies the presence of a class I integron with the aadA1 gene cassette and an SXT constin in Vibrio cholerae O1 strains from Laos, which confer resistance to multiple antibiotics including streptomycin, chloramphenicol, tetracycline, and sulfamethoxazole.

Gene Information

Gene Name: tetA
Allele: tetA
Encodes: tetracycline resistance
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Vibrio cholerae O1
Geographic Location: Laos
Validation Method: PCR and sequencing
Sequence Accession: AB115497

Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada.

PMID 15388431 · 2004

The study reports the complete nucleotide sequence of a 92-kilobase plasmid, pC15-1a, which harbors the CTX-M-15 extended-spectrum beta-lactamase, along with other resistance genes such as blaOXA-1, blaTEM-1, aac(6')-Ib, aac(3)-II, and tetA. These genes contribute to multidrug resistance in Escherichia coli strains associated with an outbreak in long-term-care facilities in Toronto, Canada.

Gene Information

Gene Name: tetA
Allele: tetA
Encodes: tetracycline resistance protein
Source Database: Reslit
Mechanism: efflux of tetracycline
Confers Resistance To: tetracycline
Organisms Tested In: • Escherichia coli
Geographic Location: Toronto, Canada|Vancouver, Canada|India
Validation Method: plasmid sequencing and confirmation of tetracycline resistance
Sequence Accession: AY458016

Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins.

PMID 15388464 · 2004

Gene Information

Gene Name: tetA
Allele: tetA
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Escherichia coli
Validation Method: PCR and sequencing

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