tetA(58)

tetracycline efflux ABC transporter Tet(58) subunit A

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic efflux
Validation Method: Metagenomic analysis
Drug Classes: TETRACYCLINE, Tetracycline, Oxytetracycline, Doxycycline
Organisms: Paenibacillus sp. LC231, Streptococcus equi subsp. equi, Nocardia cyriacigeorgica, Nocardia species
Geographic Location: China
Papers: 5
Databases: Card DatabaseReference Gene CatalogReslit

Papers5

A diverse intrinsic antibiotic resistome from a cave bacterium.

PMID 27929110 · 2016

Gene Information

Gene Name: tetA(58)
Allele: tetA(58)
Encodes: tetracycline efflux ABC transporter Tet(58) subunit A
Source Database: Reference Gene Catalog
Mechanism: antibiotic efflux
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • Paenibacillus sp. LC231
Sequence Accession: KX531044.1
Protein Accession: APB03214.1
Notes: ARO:3003980

A diverse intrinsic antibiotic resistome from a cave bacterium.

PMID 27929110 · 2016

Gene Information

Gene Name: tetA(58)
Allele: tetA(58)
Encodes: tetracycline efflux ABC transporter Tet(58) subunit A, major facilitator superfamily (MFS) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • Paenibacillus sp. LC231
Sequence Accession: KX531044.1
Protein Accession: APB03214.1
Notes: ARO:3003980

Sulfur: a neglected driver of the increased abundance of antibiotic resistance genes in agricultural reclaimed subsidence land located in coal mines with high phreatic water levels.

PMID 36994396 · 2023

This study identifies several antibiotic resistance genes (ARGs) in reclaimed soil, highlighting the role of sulfur in increasing the abundance of ARGs. The most abundant ARGs included MacB, tetA(58), bcrA, novA, and evgS, primarily associated with efflux pump mechanisms.

Gene Information

Gene Name: tetA(58)
Allele: tetA(58)
Encodes: major facilitator superfamily transporter
Source Database: Reslit
Mechanism: efflux pump
Confers Resistance To: Tetracycline
Geographic Location: China
Validation Method: Metagenomic analysis

Complete genome sequencing and comparative genomic analysis of three donkey Streptococcus equi subsp. equi isolates.

PMID 38029076 · 2023

The study identified multiple antibiotic resistance genes in three donkey-derived Streptococcus equi subsp. equi isolates, including genes conferring resistance to beta-lactams, tetracyclines, macrolides, fluoroquinolones, and others. Notably, the HT1112 isolate showed resistance to six antimicrobials, while HTP133 and HTP232 showed resistance to fewer drugs. Additionally, the study highlighted the role of biofilm formation in antimicrobial resistance.

Gene Information

Gene Name: tetA(58)
Allele: tetA(58)
Encodes: tetracycline resistance protein
Source Database: Reslit
Mechanism: tetracycline resistance
Confers Resistance To: TetracyclineOxytetracyclineDoxycycline
Organisms Tested In: • Streptococcus equi subsp. equi
Geographic Location: China
Validation Method: antimicrobial susceptibility testing
Sequence Accession: CP133957|CP133955|CP133956

Genomic characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic insights into Nocardia cyriacigeorgica.

PMID 40188140 · 2025

The study identified several antimicrobial resistance genes in Nocardia cyriacigeorgica, including VanSO and VanRO for vancomycin resistance, erm(O)-Irm, srmB, and ermH for macrolide resistance, bla1 and bcl for beta-lactam resistance, CTX-M and KPC for cephalosporin and carbapenem resistance, tetA(58) and tetB(58) for tetracycline resistance, folC and folP for sulfonamide resistance, rbpA and rpoB2 for rifamycin resistance, murA and AbaF for fosfomycin resistance, cmlR for chloramphenicol resistance, and VatF and VatE for streptogramin resistance.

Gene Information

Gene Name: tetA(58)
Allele: tetA(58)
Encodes: Tetracycline efflux pump gene
Source Database: Reslit
Mechanism: confers resistance to tetracyclines by actively pumping out the antibiotics
Confers Resistance To: Tetracycline
Organisms Tested In: • Nocardia cyriacigeorgica
Geographic Location: China
Validation Method: BLASTP against CARD database
Sequence Accession: SAMN46383565|GCA_027924465.1|GCA_010858005.1|SAMN46383563|GCA_015477225.1|GCA_015477975.1|GCA_000284035.1|GCA_015477645.1|GCA_029868645.1|GCA_027924275.1|GCA_010868115.1|GCA_010868145.1|GCA_010868155.1|GCA_029868385.1|GCA_005863245.1|GCA_005863295.1|GCA_015478165.1|GCA_015478435.1|GCA_015478155.1|SAMN46383564|GCA_015478075.1|GCA_010858045.1|GCA_015477995.1|SAMN46383566|GCA_015477865.1|GCA_029868465.1|GCA_900683635.1|GCA_015478375.1|GCA_015477145.1|GCA_015477345.1|GCA_015477725.1|GCA_015478465.1|SAMN46383567|GCA_015476895.1|GCA_015476905.1|GCA_015476925.1|GCA_015477945.1|GCA_015478055.1|GCA_029868825.1|GCA_002933455.1|GCA_029868925.1|GCA_029868665.1|GCA_029868765.1|GCA_029868805.1|GCA_029869825.1|GCA_029868685.1|GCA_029868705.1|GCA_002949635.1|GCA_029868265.1|GCA_029867605.1|GCA_029869675.1|GCA_029869725.1|GCA_029867685.1|GCA_029867665.1|GCA_029867565.1|GCA_000308555.1|GCA_005863225.1|GCA_029867425.1|GCA_029868785.1|GCA_029868005.1|PRJNA1214743

Genomic and phenotypic characterization of antimicrobial resistance in clinical Nocardia species isolates.

PMID 41050760 · 2025

Gene Information

Gene Name: tetA(58)
Allele: tetA(58)
Encodes: tetracycline resistance
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Nocardia species
Validation Method: genomic analysis and phenotypic correlation

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tetA(58)

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