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Explore antimicrobial resistance genes from the literature

tetA(60)

ABC half transporter

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to tetA(60)

Browse AMR rules for tetA(60)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Increased efflux
Validation Method: mutagenesis studies and MIC assays
Drug Classes: Tetracycline, Tigecycline, TETRACYCLINE, TIGECYCLINE, DOXYCYCLINE
Organisms: Escherichia coli, uncultured bacterium, Salmonella enterica subsp. enterica serovar Enteritidis, Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica, Streptococcus sp.
Geographic Location: Europe|Denmark|France|Germany|United Kingdom, Hanoi, Vietnam, Kuwait
Alleles: 2
Papers: 5
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
tetA(60)	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	6	Tetracycline, Tigecycline +3	Escherichia coli +2	-

Papers5

1

Eﬄux in the Oral Metagenome: The Discovery of a Novel Tetracycline and Tigecycline ABC Transporter.

PMID 27999567 · 2016

The study identifies two novel genes, tetA(60) and tetB(60), which encode a heterodimeric ABC transporter responsible for tetracycline and tigecycline resistance in E. coli. The resistance mechanism involves the combined action of both genes, and the transporter exhibits a fitness cost in the host.

Gene Information

Gene Name: tetA(60)
Allele: tetA(60)
Encodes: ABC half transporter
Source Database: Reslit
Confers Resistance To: TetracyclineTigecycline
Organisms Tested In: • Escherichia coli
Validation Method: mutagenesis studies and MIC assays
Sequence Accession: KX000272.1|KX000273.1|KX887332

2

Eﬄux in the Oral Metagenome: The Discovery of a Novel Tetracycline and Tigecycline ABC Transporter.

PMID 27999567 · 2016

Gene Information

Gene Name: tetA(60)
Allele: tetA(60)
Encodes: tetracycline efflux ABC transporter Tet(60) subunit A
Source Database: Reference Gene Catalog
Mechanism: Increased efflux
Confers Resistance To: TETRACYCLINETIGECYCLINEDOXYCYCLINE
Organisms Tested In: • uncultured bacterium
Sequence Accession: KX000272.1
Protein Accession: ANZ79240.1
Notes: Both tetA(60) and tetB(60) must be present to confer resistance

3

Eﬄux in the Oral Metagenome: The Discovery of a Novel Tetracycline and Tigecycline ABC Transporter.

PMID 27999567 · 2016

Gene Information

Gene Name: tetA(60)
Allele: tetA(60)
Encodes: tetracycline efflux ABC transporter Tet(60) subunit A
Source Database: ResFinder Database
Mechanism: Increased efflux
Confers Resistance To: TETRACYCLINETIGECYCLINEDOXYCYCLINE
Organisms Tested In: • uncultured bacterium
Sequence Accession: KX000272.1
Protein Accession: ANZ79240.1
Notes: Both tetA(60) and tetB(60) must be present to confer resistance

4

Eﬄux in the Oral Metagenome: The Discovery of a Novel Tetracycline and Tigecycline ABC Transporter.

PMID 27999567 · 2016

Gene Information

Gene Name: tetA(60)
Allele: tetA(60)
Encodes: tetracycline efflux ABC transporter Tet(60) subunit A, ATP-binding cassette (ABC) antibiotic efflux pump
Source Database: Card Database
Mechanism: Increased efflux, antibiotic efflux
Confers Resistance To: TETRACYCLINETIGECYCLINEDOXYCYCLINE
Organisms Tested In: • uncultured bacterium
Sequence Accession: KX000272.1
Protein Accession: ANZ79240.1
Notes: Both tetA(60) and tetB(60) must be present to confer resistance, ARO:3004035

5

Non-typhoidal Salmonella blood stream infection in Kuwait: Clinical and microbiological characteristics.

PMID 30986214 · 2019

The study identified several AMR genes and mutations in non-typhoidal Salmonella isolates from Kuwait, including aac(6')-Iaa_1, aph(3'')-Ib_5, aph(3')-Ia_1, aph(6)-Id_1, blaCARB-2_1, blaTEM-1B_1, dfrA5_1, floR_2, sul2_2, tet(A)_6, tet(G)_2, and mutations in the gyrA gene. These genes and mutations were associated with resistance to various antibiotics such as aminoglycosides, beta-lactams, trimethoprim, chloramphenicol, sulfamethoxazole, tetracycline, and fluoroquinolones.

Gene Information

Gene Name: tetA(60)
Allele: tet(A)_6
Encodes: Tetracycline resistance
Source Database: Reslit
Mechanism: Ribosomal protection
Confers Resistance To: Tetracycline
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Enteritidis
• Salmonella enterica subsp. enterica serovar Typhimurium
Geographic Location: Kuwait
Validation Method: Whole genome sequencing
Sequence Accession: PRJNA363099

6

The Spatiotemporal Dynamics and Microevolution Events That Favored the Success of the Highly Clonal Multidrug-Resistant Monophasic Salmonella Typhimurium Circulating in Europe.

PMID 34093465 · 2021

The study identifies various AMR genes in the highly clonal multidrug-resistant monophasic Salmonella Typhimurium ST34, including beta-lactamases, sulfonamide resistance genes, tetracycline resistance genes, phenicol resistance genes, and polymyxin resistance genes.

Gene Information

Gene Name: tetA(60)
Allele: tet(A)_6
Encodes: tetracycline resistance
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Salmonella enterica
Geographic Location: Europe|Denmark|France|Germany|United Kingdom
Validation Method: plasmid analysis and sequencing
Sequence Accession: MF684783.1|CP055956.1|CP057682.1|CP055697.1|KF152885|HQ023861|KC853435.1|CP039562.1|MF543359.1

7

Whole-Genome Analysis of Antimicrobial-Resistant Salmonella enterica Isolated from Duck Carcasses in Hanoi, Vietnam.

PMID 36975513 · 2023

The study identified 43 antibiotic resistance genes in Salmonella enterica isolates from duck carcasses in Hanoi, Vietnam, including genes conferring resistance to multiple antibiotic classes such as aminoglycosides, beta-lactams, quinolones, and tetracyclines.

Gene Information

Gene Name: tetA(60)
Allele: tet(A)_6
Encodes: tetracycline resistance protein
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Salmonella enterica
Geographic Location: Hanoi, Vietnam
Validation Method: whole-genome sequencing
Sequence Accession: SRR16611133|SRR16611134|SRR16611135|SRR16611136|SRR16611137|SRR16611138|SRR16611139|SRR16611140

8

PMID unpublished

Gene Information

Gene Name: tetA(60)
Allele: tetA(60)
Source Database: ResFinder Database
Mechanism: Increased efflux
Confers Resistance To: TETRACYCLINETIGECYCLINEDOXYCYCLINE
Organisms Tested In: • uncultured bacterium
Sequence Accession: KX000272
Notes: Both tetA(60) and tetB(60) must be present to confer resistance

9

Gene Information

Gene Name: tetA(60)
Allele: tetA(60)
Encodes: tetracycline efflux ABC transporter Tet(60) subunit A
Source Database: Reference Gene Catalog
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • Streptococcus sp.
Sequence Accession: JABZZA010000077.1
Protein Accession: MBF1732492.1