tetA(P)

transmembrane protein

Validation StatusCandidate

Overview

Mechanism: active efflux of tetracycline
Validation Method: mutagenesis and MIC determination
Drug Classes: tetracycline
Organisms: Clostridium perfringens, Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Transcriptional analysis of the tet(P) operon from Clostridium perfringens.

PMID 11717269 · 2001

The study identifies and characterizes the tetA(P) and tetB(P) genes from the Clostridium perfringens tetracycline resistance determinant, which are part of an operon transcribed from a single promoter, P3. Both genes contribute to tetracycline resistance through different mechanisms: tetA(P) mediates active efflux, while tetB(P) provides ribosomal protection.

Gene Information

Gene Name: tetA(P)
Allele: TetA(P)
Encodes: transmembrane protein
Source Database: Reslit
Mechanism: active efflux of tetracycline
Confers Resistance To: tetracycline
Organisms Tested In: • Clostridium perfringens
• Escherichia coli
Validation Method: mutagenesis and MIC determination
Sequence Accession: L20800

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tetA(P)

Gene Information