tetB(60)

ABC half transporter

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Increased efflux
Validation Method: mutagenesis studies and MIC assays
Drug Classes: Tetracycline, Tigecycline, TETRACYCLINE, TIGECYCLINE, DOXYCYCLINE
Organisms: Escherichia coli, uncultured bacterium, human saliva metagenomic library, Mycobacterium abscessus, Mycobacterium massiliense, Mycobacterium bolletii, Streptococcus sp.
Geographic Location: Atlantic Southwest Shelves Province|Antarctic Province|Indian South Subtropical Gyre
Papers: 4
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Papers4

Eﬄux in the Oral Metagenome: The Discovery of a Novel Tetracycline and Tigecycline ABC Transporter.

PMID 27999567 · 2016

The study identifies two novel genes, tetA(60) and tetB(60), which encode a heterodimeric ABC transporter responsible for tetracycline and tigecycline resistance in E. coli. The resistance mechanism involves the combined action of both genes, and the transporter exhibits a fitness cost in the host.

Gene Information

Gene Name: tetB(60)
Allele: tetB(60)
Encodes: ABC half transporter
Source Database: Reslit
Confers Resistance To: TetracyclineTigecycline
Organisms Tested In: • Escherichia coli
Validation Method: mutagenesis studies and MIC assays
Sequence Accession: KX000272.1|KX000273.1|KX887332

Eﬄux in the Oral Metagenome: The Discovery of a Novel Tetracycline and Tigecycline ABC Transporter.

PMID 27999567 · 2016

Gene Information

Gene Name: tetB(60)
Allele: tetB(60)
Encodes: tetracycline efflux ABC transporter Tet(60) subunit B
Source Database: Reference Gene Catalog
Mechanism: Increased efflux
Confers Resistance To: TETRACYCLINETIGECYCLINEDOXYCYCLINE
Organisms Tested In: • uncultured bacterium
Sequence Accession: KX000273.1
Protein Accession: ANZ79241.1
Notes: Both tetA(60) and tetB(60) must be present to confer resistance

Eﬄux in the Oral Metagenome: The Discovery of a Novel Tetracycline and Tigecycline ABC Transporter.

PMID 27999567 · 2016

Gene Information

Gene Name: tetB(60)
Allele: tetB(60)
Encodes: tetracycline efflux ABC transporter Tet(60) subunit B
Source Database: ResFinder Database
Mechanism: Increased efflux
Confers Resistance To: TETRACYCLINETIGECYCLINEDOXYCYCLINE
Organisms Tested In: • uncultured bacterium
Sequence Accession: KX000273.1
Protein Accession: ANZ79241.1
Notes: Both tetA(60) and tetB(60) must be present to confer resistance

Eﬄux in the Oral Metagenome: The Discovery of a Novel Tetracycline and Tigecycline ABC Transporter.

PMID 27999567 · 2016

Gene Information

Gene Name: tetB(60)
Allele: tetB(60)
Encodes: tetracycline efflux ABC transporter Tet(60) subunit B, ATP-binding cassette (ABC) antibiotic efflux pump
Source Database: Card Database
Mechanism: Increased efflux, antibiotic efflux
Confers Resistance To: TETRACYCLINETIGECYCLINEDOXYCYCLINE
Organisms Tested In: • uncultured bacterium
Sequence Accession: KX000273.1
Protein Accession: ANZ79241.1
Notes: Both tetA(60) and tetB(60) must be present to confer resistance, ARO:3004036

Global ocean resistome revealed: Exploring antibiotic resistance gene abundance and distribution in TARA Oceans samples.

PMID 32391909 · 2020

The study identified 313 ARGs in the global ocean, including mcr-1, which confers resistance to colistin. The most frequent ARGs were Qac and TETB(60), associated with multidrug efflux pumps and tetracycline resistance, respectively.

Gene Information

Gene Name: tetB(60)
Allele: tetB(60)
Encodes: ABC transporter
Source Database: Reslit
Confers Resistance To: TetracyclineTigecycline
Organisms Tested In: • human saliva metagenomic library
Geographic Location: Atlantic Southwest Shelves Province|Antarctic Province|Indian South Subtropical Gyre
Validation Method: deepARG screening

The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.

PMID 36261788 · 2022

The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.

Gene Information

Gene Name: tetB(60)
Allele: tetB(60)
Encodes: efflux protein
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Mycobacterium abscessus
• Mycobacterium massiliense
• Mycobacterium bolletii
Validation Method: gene characterization in strains

PMID unpublished

Gene Information

Gene Name: tetB(60)
Allele: tetB(60)
Source Database: ResFinder Database
Mechanism: Increased efflux
Confers Resistance To: TETRACYCLINETIGECYCLINEDOXYCYCLINE
Organisms Tested In: • uncultured bacterium
Sequence Accession: KX000273
Notes: Both tetA(60) and tetB(60) must be present to confer resistance

PMID N/A

Gene Information

Gene Name: tetB(60)
Allele: tetB(60)
Encodes: tetracycline efflux ABC transporter Tet(60) subunit B
Source Database: Reference Gene Catalog
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • Streptococcus sp.
Sequence Accession: JABZYV010000008.1
Protein Accession: MBF1719776.1

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tetB(60)

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