tetB(P)

ribosomal protection protein

Validation StatusCandidate

Overview

Mechanism: ribosomal protection
Validation Method: PCR and sequencing
Drug Classes: tetracycline
Organisms: Clostridium perfringens, Escherichia coli, Streptomyces lividans, Streptomyces rimosus
Papers: 2
Databases: Reslit

Papers2

Molecular ecology of tetracycline resistance: development and validation of primers for detection of tetracycline resistance genes encoding ribosomal protection proteins.

PMID 11133424 · 2001

The study identified and characterized multiple tetracycline resistance genes encoding ribosomal protection proteins (RPPs) including tet(M), tet(O), tet(W), tet(Q), tet(S), tet(T), tetB(P), and otrA. These genes were detected in various bacterial species and environments, highlighting their prevalence and potential for horizontal gene transfer.

Gene Information

Gene Name: tetB(P)
Allele: TetB(P)
Encodes: ribosomal protection protein
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Clostridium perfringens
• Escherichia coli
• Streptomyces lividans
• Streptomyces rimosus
Validation Method: PCR and sequencing
Sequence Accession: M85225|X56353|X04388|X75073|U08812|U58986|L12241|L12242|M21136|X90939|L09756|X92946|Y07780|M20925|M18896|AJ222769|Z21523|U73497|L33696|Y08615|X58717|L42544|L20800|M74049|X53401

Transcriptional analysis of the tet(P) operon from Clostridium perfringens.

PMID 11717269 · 2001

The study identifies and characterizes the tetA(P) and tetB(P) genes from the Clostridium perfringens tetracycline resistance determinant, which are part of an operon transcribed from a single promoter, P3. Both genes contribute to tetracycline resistance through different mechanisms: tetA(P) mediates active efflux, while tetB(P) provides ribosomal protection.

Gene Information

Gene Name: tetB(P)
Allele: TetB(P)
Encodes: cytoplasmic ribosomal protection protein
Source Database: Reslit
Mechanism: ribosomal protection
Confers Resistance To: tetracycline
Organisms Tested In: • Clostridium perfringens
• Escherichia coli
Validation Method: mutagenesis and MIC determination
Sequence Accession: L20800

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tetB(P)

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