Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline resistance regulator
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| N82H | - | single resistance variant | Salmonella enterica | - | Card Database | Established |
| H64Y | - | single resistance variant | Salmonella enterica | - | Card Database | Established |
| T103I | - | single resistance variant | Salmonella enterica | - | Card Database | Established |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| tetR | Reslit | 53 | Tetracycline, Doxycycline +2 | Salmonella enterica serovar Typhimurium +37 | Italy, France, China, Ho Chi Minh City, Vietnam, UK|Cyprus, Global, Germany, Changsha, Bangladesh, United States, Spain|porcine, Thailand, Mecklenburg-Western Pomerania, South Carolina, Peru, Japan, India, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Mexico|Japan|China|Israel|New Zealand|United States, Quebec, Canada, Greece, Southeastern U.S., Bangladesh|India|China|France|Brazil, Ghana, East China, South Africa, Europe|United States | 1999, 2002, 2004, 2005, 2006, 2009, 2011, 2013, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AF261825 | - |
| TetR | Reslit | 3 | Tetracycline | Staphylococcus aureus +2 | Thailand | 2022, 2023 | - | - |
Antibiotic Resistance Genes and Salmonella Genomic Island 1 in Salmonella enterica Serovar Typhimurium Isolated in Italy.
The study identifies antibiotic resistance genes and the presence of Salmonella Genomic Island 1 (SGI1) in multidrug-resistant Salmonella enterica serovar Typhimurium isolates from Italy. Key resistance genes include aadA2, pse-1, floR, tetA, and tetR, which contribute to resistance against various antibiotics.
Combining mathematical models and statistical methods to understand and predict the dynamics of antibiotic-sensitive mutants in a population of resistant bacteria during experimental evolution.
The study identified the deletion of the tetracycline-resistance operon (tetA and tetR) in E. coli K12(pB10) as the cause of tetracycline sensitivity, demonstrating that this deletion occurred through recombination between direct repeats on the plasmid.
Tetracycline-inducible gene regulation in mycobacteria.
The study describes a tetracycline-inducible gene regulation system in mycobacteria using the tetRO region from Corynebacterium glutamicum's TetZ determinant. This system allows for controlled gene expression in both fast-growing and slow-growing mycobacteria, including M. smegmatis, M. bovis BCG, and M. tuberculosis.
Comparative genomics of multidrug resistance in Acinetobacter baumannii.
The study identifies numerous resistance genes in the multidrug-resistant Acinetobacter baumannii strain AYE, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others, highlighting the complexity of its resistance mechanisms.
Genome sequence of the versatile fish pathogen Edwardsiella tarda provides insights into its adaptation to broad host ranges and intracellular niches.
The study identifies multiple AMR genes in Edwardsiella tarda EIB202, including tetA, tetR, strA, strB, sulII, and catA3, which confer resistance to tetracycline, streptomycin, sulfonamide, and chloramphenicol.
Stochastic simulations of the tetracycline operon.
The study investigates the dynamics of the tetracycline operon, focusing on the genes tetR and tetA, which encode the repressor protein TetR and the transport protein TetA, respectively. These genes are crucial for tetracycline resistance in bacteria.
Acquired genetic mechanisms of a multiresistant bacterium isolated from a treatment plant receiving wastewater from antibiotic production.
Title of the Paper
The study characterizes antibiotic-resistant Staphylococcus aureus strains (EryR, KanR, TetR) and demonstrates that sub-curative antibiotic doses can selectively expand resistant bacterial populations during infection.
Genetic characterization of three qnrS1-harbouring multidrug-resistance plasmids and qnrS1-containing transposons circulating in Ho Chi Minh City, Vietnam.
The study characterizes three qnrS1-harbouring multidrug-resistance plasmids and identifies qnrS1-containing transposons circulating in Ho Chi Minh City, Vietnam. It reveals that qnrS1 is part of a transposon structure that includes additional resistance genes such as blaLAP-2, aacC3, sulII, tetR, tetA, and blaCTX-M-14.
ICEApl1, an Integrative Conjugative Element Related to ICEHin1056, Identified in the Pig Pathogen Actinobacillus pleuropneumoniae.
The study identifies ICEApl1, an integrative conjugative element in Actinobacillus pleuropneumoniae, which contains tetracycline resistance genes tetB, tetC, tetD, and tetR. This element confers tetracycline resistance and was found in serovar 8 isolates.
Outer Membrane Proteins form Specific Patterns in Antibiotic-Resistant Edwardsiella tarda.
The study identifies specific outer membrane protein patterns associated with antibiotic resistance in Edwardsiella tarda, highlighting the role of plasmid-encoded genes such as tetA, tetR, and catA in mediating resistance to tetracycline and chloramphenicol.
Characterization of a Large Antibiotic Resistance Plasmid Found in Enteropathogenic Escherichia coli Strain B171 and Its Relatedness to Plasmids of Diverse E. coli and Shigella Strains.
The study characterized a large antibiotic resistance plasmid, pB171_90, from EPEC strain B171, identifying several AMR genes including aadA1, sul1, tetA, tetR, qacE Δ 1, csi, hha, and traI.
ARIBA: Rapid identification of antimicrobial resistance genes and variants from whole-genome sequencing data
The paper presents ARIBA, a tool for identifying antimicrobial resistance genes and mutations from sequencing data. It evaluates the performance of ARIBA on three datasets, demonstrating its accuracy and efficiency in detecting resistance genes and mutations in Enterococcus faecium, Shigella sonnei, and Neisseria gonorrhoeae.
High genomic diversity of multi-drug resistant wastewater Escherichia coli.
The study identifies several known and novel resistance genes in wastewater-derived E. coli, highlighting the high genomic diversity and the presence of genes associated with resistance to various antibiotics.
Whole Genome Sequencing and Comparative Genomics Analyses of Pandoraea sp. XY-2, a New Species Capable of Biodegrade Tetracycline.
The study identifies two tetracycline resistance genes, tetR and tetG, in Pandoraea sp. XY-2, suggesting its capability to biodegrade tetracycline.
Adaptation of metal and antibiotic resistant traits in novel β-Proteobacterium Achromobacter xylosoxidans BHW-15.
The study identifies multiple antibiotic resistance genes in Achromobacter xylosoxidans BHW-15, including beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps, contributing to resistance against beta-lactams, aminoglycosides, and other antibiotics.
Edwardsiella piscicida: A versatile emerging pathogen of fish.
The study identifies multiple antibiotic resistance genes in Edwardsiella piscicida, including tetA, tetR, strA, strB, sulII, and catA3, which confer resistance to tetracycline, streptomycin, sulfonamides, and chloramphenicol.
Characterization of a Novel Conjugative Plasmid in Edwardsiella piscicida Strain MS-18-199.
The study characterizes a novel conjugative plasmid, pEPMS-18199, in Edwardsiella piscicida strain MS-18-199, which carries multiple antimicrobial resistance (AMR) genes including floR, tetA, tetR, sul2, strA, strB, arsA, and arsD, conferring resistance to phenicol, tetracycline, sulfonamide, and aminoglycoside antibiotics, as well as arsenic.
Whole Genome Sequencing and Characteristics of mcr-1-Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B.
The study identified the mcr-1.1 gene in five porcine E. coli isolates, which confers resistance to colistin. The gene was found on various plasmids, including IncF, IncX4, and IncHI2, highlighting the role of mobile genetic elements in the spread of colistin resistance.
AcGI1, a novel genomic island carrying antibiotic resistance integron In687 in multidrug resistant Achromobacter xylosoxidans in a teaching hospital in Thailand.
The study identifies a novel genomic island, AcGI1, carrying the carbapenem resistance gene blaIMP-14a and other resistance genes in multidrug-resistant Achromobacter xylosoxidans strains from Thailand.
Comparison of antimicrobial resistant genes in chicken gut microbiome grown on organic and conventional diet.
The study identified various antimicrobial resistance genes in the gut microbiome of chickens raised on organic and conventional diets, including beta-lactamases, multidrug efflux systems, aminoglycoside modifying enzymes, and tetracycline resistance genes. These genes were found to be more prevalent in conventional diet samples under higher antibiotic concentrations.
Characteristics and Epidemiology of Extended-Spectrum β-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae From Red Kangaroo, China.
The study identified multiple AMR genes in a multidrug-resistant Klebsiella pneumoniae isolate from a Red Kangaroo, including beta-lactamases (bla DHA–3, bla SHV–1, bla CTX–M–14, bla TEM–191, bla TEM–1, bla CTX–M–3), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aac(3)-IIa, aac(6′)-Ib-cr, aadA16, arr-3), quinolone resistance genes (qnrS1, qnrB2), macrolide resistance gene (mphA), sulfonamide resistance genes (sul3, sul1), dihydrofolate reductase (dfrA3, dfrA27), chloramphenicol resistance gene (floR), tetracycline resistance genes (tetG, tetR), and multidrug efflux pump (qacEΔ1).
Complete genome analysis of a virulent Vibrio scophthalmi strain VSc190401 isolated from diseased marine fish half-smooth tongue sole, Cynoglossus semilaevis.
The study identified several AMR genes in Vibrio scophthalmi strain VSc190401, including those conferring resistance to aminoglycosides, fluoroquinolones, tetracyclines, and polymyxins. Some of these genes were validated experimentally.
Diversity of Plasmids and Genes Encoding Resistance to Extended-Spectrum β-Lactamase in Escherichia coli from Different Animal Sources.
The study identified various AMR genes and mutations in E. coli isolates from different animal sources, highlighting the presence of ESBL genes such as bla CTX-M-15, bla TEM-1B, and bla CMY-28, as well as mutations in parC and gyrA that confer resistance to fluoroquinolones.
Genomic Analysis of ESBL-Producing E. coli in Wildlife from North-Eastern Germany.
The study identified ESBL-producing E. coli in wild boar and wild ruminants with a low prevalence. The most prevalent ESBL type was CTX-M-1. The study also found resistance genes for aminoglycosides, phenicol, sulfonamides, and tetracyclines.
Oxytetracycline and Streptomycin Resistance Genes in Xanthomonas arboricola pv. pruni, the Causal Agent of Bacterial Spot in Peach.
The study identifies tetC, tetR, and strAB as the genes responsible for oxytetracycline and streptomycin resistance in Xanthomonas arboricola pv. pruni. These genes are located on a multidrug-resistant plasmid and can be transferred to other bacterial species via conjugation.
Nutrient Gradients Mediate Complex Colony-Level Antibiotic Responses in Structured Microbial Populations.
The study characterizes the tetracycline resistance mechanism involving the tet operon in E. coli, highlighting the role of TetA efflux pump and TetR repressor in regulating resistance. It reveals how transient growth in the colony interior enhances resistance gene expression, contributing to population-level resistance.
Nutrient Gradients Mediate Complex Colony-Level Antibiotic Responses in Structured Microbial Populations.
The study characterizes the tetracycline resistance mechanism involving the tet operon in E. coli, highlighting the role of TetA efflux pump and TetR repressor in regulating resistance. It reveals how transient growth in the colony interior enhances resistance gene expression, contributing to population-level resistance.
Distribution of ESBL/AmpC-Escherichia coli on a Dairy Farm.
The study identified ESBL/AmpC-producing E. coli on a dairy farm, with a high prevalence in calves. Key resistance genes included blaCTX-M-1, blaCTX-M-15, floR, strA, strB, catA, aadA, dfrA, tetA, tetR, tetY, mph(A), and TEM-105.
WGS-Based Lineage and Antimicrobial Resistance Pattern of Salmonella Typhimurium Isolated during 2000-2017 in Peru.
The study identifies 63 different AMR genes in 90 S. Typhimurium isolates from Peru, including beta-lactamases (blaTEM-181, blaSHV-12, blaSHV-134, blaCTX-M-15), quinolone resistance genes (qnrB5, qnrB19, qnrE2), tetracycline resistance genes (tetA, tetD, tetR), sulfonamide resistance genes (sul3), dihydrofolate reductase (dfrA1, dfrA12), florfenicol resistance gene (floR), lincomycin resistance gene (linG), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aadA2), colistin resistance gene (mcr-1), and fosfomycin resistance gene (fosA3).
Antimicrobial resistance and associated genetic background of Histophilus somni isolated from clinically affected and healthy cattle.
The study identified several AMR genes in Histophilus somni isolates, including bla ROB - 1, aphA-1, strA, strB, tetH, and tetR, which are associated with resistance to ampicillin, amoxicillin, kanamycin, streptomycin, and oxytetracycline. These genes were found in isolates from respiratory diseases and were linked to increased MICs.
Diversity of resistant determinants, virulence factors, and mobile genetic elements in Acinetobacter baumannii from India: A comprehensive in silico genome analysis.
The study identified multiple antibiotic resistance genes (ARGs) in 47 Acinetobacter baumannii isolates from India, including blaOXA-23, blaADC-73, aac(3)-I, aadA, aph(3')-Ib, sul1, sul2, and lpsB. These genes contribute to resistance against carbapenems, cephalosporins, aminoglycosides, sulfonamides, and polymyxins.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Metaproteomic Analysis of Gut Resistome in the Cecal Microbiota of Fattening Pigs Raised without Antibiotics.
The study identified several AMR genes, including APH(3'), CTX-M-14, ArnA, MdtL, CatB2, TetQ, TetR, Cas1, and Cas9, in the cecal microbiota of pigs raised with and without antibiotics. These genes were associated with resistance to aminoglycosides, beta-lactams, polymyxin, tetracycline, and other antibiotics.
On the use of antibiotics to control plant pathogenic bacteria: a genetic and genomic perspective.
The study identifies several AMR genes and mutations associated with streptomycin, kasugamycin, gentamicin, and oxytetracycline resistance in plant pathogenic bacteria, highlighting the role of Tn 5393 and other mobile genetic elements in the dissemination of these resistance traits.
Genomic Characterization of a Tetracycline-Resistant Strain of Brochothrix thermosphacta Highlights Plasmids Partially Shared between Various Strains.
The study identifies three plasmids in the tetracycline-resistant strain B. thermosphacta BT469, including pBT469-2 carrying the tet(L) gene responsible for tetracycline resistance and pBT469-1 containing the tetR and qacH genes.
The Resistance and Virulence Characteristics of Salmonella Enteritidis Strain Isolated from Patients with Food Poisoning Based on the Whole-Genome Sequencing and Quantitative Proteomic Analysis.
The study identified multiple antimicrobial resistance genes in the multidrug-resistant Salmonella Enteritidis strain 27A, including beta-lactamase blaTEM-194, aminoglycoside resistance genes aac(6)-Ib, aac(6)-If, aph(3”)-Ib, and aph(6)-Id, tetracycline resistance genes tetA, tetR, and tet34, and efflux pump genes acrA, acrB, tolC, oprM, mexE, mexF, macB, mdtG, mdtH, mdtL, mdtM, mdtK, rosA, emrA, emrR, ykkc, and vanRA.
Polyinfection in Fish Aeromoniasis: A Study of Co-Isolated Aeromonas Species in Aeromonas veronii Outbreaks.
The study identified the tetracycline resistance gene tetE and the quinolone resistance gene qnrB in Aeromonas salmonicida AG2.13.2 and Aeromonas rivipollensis AG2.13.5, indicating their resistance to tetracycline, oxytetracycline, and quinolones.
Tulathromycin metaphylaxis increases nasopharyngeal isolation of multidrug resistant Mannheimia haemolytica in stocker heifers.
The study found that tulathromycin metaphylaxis increased the isolation of multidrug-resistant (MDR) Mannheimia haemolytica (MH) in stocker heifers. MDR MH isolates were associated with integrative conjugative elements (ICE) carrying antimicrobial resistance genes.
Dynamics of drug delivery determines course of evolution of antibiotic responses in bacteria.
The study identified mutations in the acrB gene leading to upregulation of the efflux pump and mutations in the tetR gene causing loss of TetR function, both contributing to tetracycline resistance in E. coli under different drug administration regimens.
Low temperatures do not impair the bacterial plasmid conjugation on poultry meat.
The study demonstrates that non-pathogenic E. coli can acquire an IncB/O-plasmid carrying multiple antimicrobial resistance genes through conjugation on poultry meat, even at low temperatures. This highlights the potential risk of antimicrobial resistance spread through food products.
Dynamical model of antibiotic responses linking expression of resistance genes to metabolism explains emergence of heterogeneity during drug exposures.
The study presents a mathematical model explaining how the expression of tetracycline resistance genes (tetA and tetR) interacts with cellular metabolism to influence heterogeneity in bacterial responses to antibiotics.
Unveiling distinct genetic features in multidrug-resistant Escherichia coli isolated from mammary tissue and gut of mastitis induced mice.
The study identified multiple antimicrobial resistance genes in multidrug-resistant E. coli strains isolated from mastitis-induced mice, highlighting the complex resistome and potential for horizontal gene transfer.
Synonymous codon substitutions modulate transcription and translation of a divergent upstream gene by modulating antisense RNA production.
Synonymous codon substitutions in the cat gene can increase tetR expression by activating an intragenic TSS, leading to higher TetR protein levels and subsequent repression of cat transcription.
Genomic analysis of Enterobacteriaceae from colorectal cancer patients at a tertiary hospital in Ghana: a case-control study.
The study identified various antimicrobial resistance genes in Enterobacteriaceae isolated from colorectal cancer patients and healthy controls, including ampC2, ampH, strA, strB, mphA, sul1, sul2, tetA, tetR, and dfrA14.
Molecular Epidemiology and Genetic Characterization of Carbapenem-Resistant Acinetobacter baumannii Isolates from the ICU of a Tertiary Hospital in East China.
The study identified 48 antimicrobial resistance genes (ARGs) in 39 carbapenem-resistant Acinetobacter baumannii (CRAB) isolates, including blaOXA-66, blaOXA-23, blaADC-30, blaADC-73, gyrA, ant(3")-IIa, aph(3")-Ib, aph(6)-Id, tetB, tetR, sul1, sul2, LpsB, LpxC, and LpxA, which confer resistance to various antibiotics such as carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, tetracycline, and sulfonamides.
Strict relationship between phenotypic and plasmid-associated genotypic of multidrug-resistant Escherichia coli isolated from Taihe Black-Boned Silky Fowl farms.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from Taihe Black-Boned Silky Fowl farms, including blaTEM, blaOXA-10, tetA, tetR, floR, cmlA, qnrS, strA, strB, aadA, aac(3)-IId, sul, and dfrA. These genes were associated with resistance to beta-lactams, tetracyclines, chloramphenicol, fluoroquinolones, aminoglycosides, and sulfonamides.
Whole-genome-based characterization of Escherichia albertii strains isolated from paediatric diarrhoeal cases in Kolkata, India.
The study identified several antimicrobial resistance genes in Escherichia albertii isolates, including beta-lactamases (bla CTX-M-55, bla TEM-105), quinolone resistance genes (qnrS1, qnrB32), sulfonamide resistance gene (sul2), tetracycline resistance genes (tetA, tetR), and trimethoprim resistance gene (dfrA1).
Drug delivery dynamics dictate evolution of bacterial antibiotic responses.
The study identified mutations in the acrB gene that enhance tetracycline efflux and loss-of-function mutations in tetR that result in constitutive expression of the TetA efflux pump, both contributing to increased tetracycline resistance in E. coli.
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
The study identified multiple antibiotic resistance genes and mutations in E. coli isolates from intensive pig farming in South Africa, highlighting the spread of resistance across the pork production continuum.
Emergence of highly virulent Aeromonas dhakensis in channel catfish aquaculture: Genomic insights into pathogenicity and antimicrobial resistance.
The study identified 60 antibiotic resistance genes in the highly virulent Aeromonas dhakensis strain CWH5, including genes conferring resistance to multiple drug classes such as beta-lactams, tetracyclines, sulfonamides, and macrolides.
Characterization of Mobile Genetic Elements and Antibiotic Resistance Genes in the Honey Bee Microbiome
The study identifies antibiotic resistance genes (ARGs) on plasmids within the honey bee gut microbiome, revealing that these plasmids exhibit broad host range and are involved in the horizontal transfer of ARGs between microbial hosts.
Diversity and antimicrobial resistance among bacterial isolates from finfish aquaculture in Thailand.
The study identified high levels of antimicrobial resistance in bacterial isolates from finfish aquaculture in Thailand, with particular emphasis on beta-lactam, tetracycline, and fluoroquinolone resistance in Gram-negative bacteria, and beta-lactam, macrolide, fluoroquinolone, and peptide resistance in Gram-positive bacteria. Unique resistance gene families, such as the SMR efflux pump and OXA beta-lactamase, were found in Aeromonas spp. and V. vulnificus.
Research of antimicrobial resistance and its associated genes distribution in Escherichia coli from diarrheic calves in the Ulagai region of China.
The study identified several antimicrobial resistance genes in E. coli isolates from diarrheic calves in the Ulagai region of China, including sul2, TEM-1, tetR, strB, QacH, floR, and CTXM-55, which were associated with resistance to various antibiotics.
Plasmid-Mediated Spread of Antibiotic Resistance by Arsenic and Microplastics During Vermicomposting.
Arsenic and microplastics significantly influenced the spread of antibiotic resistance genes (ARGs) during vermicomposting, with specific genes like bla ampC, bla LRA-1, bla FEZ-1, aph(3′)-II, ermB, vanY, mefA, catA, tetX4, bla IMP-11, aadK, ant(3′)-Ih-aac(6′)-Id, ermG, bla OXA-119, tetR, vatE, smeE, mexD, bla OXA-3, amrB, tetY, class A beta-lactamase, dfrA1, alanine adenosyltransferase JOHN-1, mdtB, mdtE, and erm-41 being enriched under various treatment conditions.
Cloning and characterization of a tetracycline resistance determinant present in Agrobacterium tumefaciens C58.
The study identifies and characterizes the tetracycline resistance genes tetA and tetR from Agrobacterium tumefaciens C58, which confer resistance to tetracycline through an efflux mechanism.
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