teta(41)

tetracycline efflux pump

Validation StatusCandidate

Overview

Validation Method: cloning in E. coli + MIC testing
Drug Classes: Tetracycline
Organisms: Serratia marcescens, Escherichia coli
Geographic Location: Savannah River site, near Aiken, SC
Papers: 2
Databases: Reslit

Papers2

Novel tetracycline resistance determinant isolated from an environmental strain of Serratia marcescens.

PMID 17308196 · 2007

A novel tetracycline resistance determinant, tetA(41), was identified in an environmental strain of Serratia marcescens. The gene encodes a tetracycline efflux pump and is regulated by the TetR(41) repressor protein.

Gene Information

Gene Name: teta(41)
Allele: tetA(41)
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Serratia marcescens
• Escherichia coli
Geographic Location: Savannah River site, near Aiken, SC
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AY264780|EF210775

Efflux-mediated drug resistance in bacteria: an update.

PMID 19678712 · 2009

The paper provides an updated overview of drug efflux pumps in bacteria, focusing on their structure, mechanisms, and roles in multidrug resistance. It highlights the importance of RND, MFS, MATE, SMR, and ABC transporters in efflux-mediated resistance.

Gene Information

Gene Name: teta(41)
Allele: tetA(41)
Encodes: tetracycline efflux protein
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Serratia marcescens
Validation Method: plasmid cloning and MIC testing

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teta(41)

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