Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline efflux pump
Overview
Multidrug-resistant Salmonella enterica serovar Muenchen from pigs and humans and potential interserovar transfer of antimicrobial resistance.
The study identifies several AMR genes in multidrug-resistant Salmonella enterica serovar Muenchen isolates from pigs and humans, including blaOXA-30, aadA2, aphA1-Iab, tetA(B), blaTEM, strA, cmlA, and tetA(A). These genes confer resistance to various antibiotics such as ampicillin, amoxicillin-clavulanic acid, streptomycin, kanamycin, tetracycline, chloramphenicol, and gentamicin.
Complete genome analysis of three Acinetobacter baumannii clinical isolates in China for insight into the diversification of drug resistance elements.
The study identifies multiple AMR genes and resistance islands in three multidrug-resistant Acinetobacter baumannii isolates, highlighting the role of genomic plasticity in the dissemination of resistance mechanisms.
Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant Acinetobacter baumannii global clone 1.
The study identified multiple mutations in genes such as parC, gyrA, acrB, adeR, and ampC that contribute to fluoroquinolone and beta-lactam resistance in Acinetobacter baumannii global clone 1. Horizontal gene transfer events, particularly the acquisition of the AbaR resistance island, played a significant role in the development of multidrug resistance.
Variant O89 O-Antigen of E. coli Is Associated With Group 1 Capsule Loci and Multidrug Resistance.
The study identified a novel O89 O-antigen locus in E. coli strain 26561, which is associated with group 1 capsule (G1C) and multidrug resistance. The strain exhibits a mucoid and viscous phenotype, and possesses multiple AMR genes including blaCTX-M-14, blaTEM-1, aph(3")-Ib, strA, aph(6)-Id, strB, aph(3′)-Ia, sul2, tetA(B), and catA1. Mutations in gyrA (S83L, D87N) and parC (S80I) contribute to quinolone resistance.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Carbapenem-Resistant Acinetobacter baumannii in U.S. Hospitals: Diversification of Circulating Lineages and Antimicrobial Resistance.
The study identifies multiple carbapenemase genes, including blaOXA-23 and blaOXA-207, as well as various resistance islands harboring genes such as aacA4, catB8, and armA, contributing to the multidrug resistance of CR Ab isolates in U.S. hospitals.
Use of genomics to explore AMR persistence in an outdoor pig farm with low antimicrobial usage.
The study identified various AMR genes in E. coli isolates from a low antimicrobial usage pig farm, highlighting the persistence of multidrug-resistant strains despite minimal selective pressure.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Identification and Characterisation of pST1023 A Mosaic, Multidrug-Resistant and Mobilisable IncR Plasmid.
The study identifies and characterizes the mosaic, multidrug-resistant, and mobilizable IncR plasmid pST1023, which carries several AMR genes including cmlA1, aadA1, aadA2, sul3, tetA(B), dfrA12, and a sil operon conferring resistance to various antibiotics and silver.
Analysis of pCl107 a large plasmid carried by an ST25 Acinetobacter baumannii strain reveals a complex evolutionary history and links to multiple antibiotic resistance and metabolic pathways.
The study identifies several antibiotic resistance genes in the plasmid pCl107 of an ST25 Acinetobacter baumannii strain, including aacA1, aacC2, strAB, sul2, and tetA(B), which confer resistance to aminoglycosides, sulfamethoxazole, and tetracycline.
The evolutionary mechanism of non-carbapenemase carbapenem-resistant phenotypes in Klebsiella spp.
The study identified bla DHA-1 as a critical gene for carbapenem resistance in K. quasipneumoniae FK688, and showed that its loss leads to decreased resistance. Other resistance genes such as qnrB4, tetA[B], arr-3, dfrA27, aadA16, qacΔE1, and sul1 were also found on the pNAR1 plasmid.
Extended-spectrum β-lactamase-producing E. coli from retail meat and workers: genetic diversity, virulotyping, pathotyping and the antimicrobial effect of silver nanoparticles.
The study identified multiple AMR genes in ESBL-producing E. coli from retail meat and workers, including bla IMP, bla TEM, bla CTX-M-1, bla VIM, bla NDM, tetA (A), tetA (B), sul, flo R, and mcr-1. These genes conferred resistance to various antibiotics such as β-lactams, tetracycline, sulfonamides, fluoroquinolones, and colistin.
Occurrence of Acinetobacter baumannii genomic resistance islands (AbGRIs) in Acinetobacter baumannii strains belonging to global clone 2 obtained from COVID-19 patients.
The study identified several AMR genes within AbGRIs in GC2 A. baumannii isolates from COVID-19 patients, including strA, strB, tetA(B), tetR(B), sul2, oxa23, aacC1, aadA1, blaTEM, armA, aacA4, aphA1b, and sul1, which confer resistance to various antibiotics such as aminoglycosides, tetracyclines, sulfonamides, carbapenems, and beta-lactams.
Antibiotic resistance, bacterial transmission and improved prediction of bacterial infection in patients with antibody deficiency.
The study identifies high levels of antibiotic resistance in respiratory tract bacteria from patients with antibody deficiency, particularly macrolide resistance genes erm(B) and mef(A), and highlights the role of commensal streptococci as reservoirs for resistance genes.
Phylogenetics and Mobilization of Genomic Traits of Cephalosporin-Resistant Escherichia coli Originated from Retail Meat.
The study identified multiple AMR genes in cephalosporin-resistant E. coli from retail meat, including bla CTX-M-1, bla SHV-12, bla CMY-2, and others, highlighting the role of mobile genetic elements in the spread of resistance.
Phenotypic and genetic heterogeneity of Acinetobacter baumannii in the course of an animal chronic infection.
The study identified a conserved colistin resistance due to a pmrB mutation in Acinetobacter baumannii isolates during a 5-year urinary tract infection in an animal patient, despite the absence of antibiotic treatment.
Identification and preclinical efficacy evaluation of two lytic bacteriophages targeting highly virulent and multidrug-resistant Klebsiella pneumoniae.
The study identifies two lytic bacteriophages, vB_KpnP_XY3 and vB_KpnP_XY4, effective against multidrug-resistant Klebsiella pneumoniae. These phages demonstrate broad temperature and pH tolerance, chloroform resistance, and potent lytic activity against MDR K. pneumoniae strains, significantly reducing bacterial load and inflammation in a murine pneumonia model.
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