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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
unknown
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| I161T | - | - | Mycobacterium tuberculosis | Para-aminosalicylic acid | Reslit | Candidate |
| - | increased promoter activity | Mycobacterium tuberculosis | Para-aminosalicylic acidPara-aminosalicyclic acid | ResFinder DatabaseReslit | Confirmed | |
| - |
| - |
| - |
PASPara-aminosalicylic acid |
Reslit |
| Candidate |
| - | - | Mycobacterium tuberculosis | Para-aminosalicylic acid | Reslit | Candidate |
| - | - | Mycobacterium tuberculosis | Para-aminosalicylic acid | Reslit | Candidate |
| - | - | - | Para-aminosalicylic acid | Reslit | Candidate |
| - | - | Mycobacterium tuberculosis | Para-aminosalicylic acid | Reslit | Candidate |
| - | increased promoter activity | Mycobacterium tuberculosis | Para-aminosalicylic acid | Reslit | Candidate |
| - | - | Mycobacterium tuberculosis | Para-aminosalicylic acid | Reslit | Candidate |
| - | - | Mycobacterium tuberculosis | Para-aminosalicylic acid | Reslit | Candidate |
Deciphering drug resistance in Mycobacterium tuberculosis using whole-genome sequencing: progress, promise, and challenges.
The paper discusses the identification of drug resistance determinants in Mycobacterium tuberculosis using whole-genome sequencing, highlighting the importance of mutations in genes such as rpoB, katG, inhA, pncA, embCAB, gyrA, gyrB, atpE, rrs, rpsL, ald, ethA, and thyX. It also identifies new resistance-associated mutations in ethA and the thyX promoter.
Whole genome sequencing reveals candidate genes involving in PAS resistance in M. Tuberculosis isolated from patients in Thailand.
The study identified mutations in thyA, thyX, folC, and ribD genes, along with intergenic regions, that contribute to PAS resistance in M. tuberculosis. These mutations were validated through complementation assays and MIC testing.
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