tlyA
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
AMR Rules
Browse AMR rules for tlyA
Validation StatusCandidate
Overview
- Papers
- 2
- Mutations
- 15
Mutations
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| Q22* | - | - | Mycobacterium tuberculosis | capreomycin|viomycinCapreomycin | ResFinderReslit | Confirmed |
| R3* | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
| R14W | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
| K69E | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
| V128E | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
| R18* | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
| P183L | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
| Q184* | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
| A67E | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
| F185L | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
| A91E | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
| E238K | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
| L118P | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
| L150P | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
| N236K | - | - | Mycobacterium tuberculosis | Capreomycin | ResFinder | Established |
Papers2
1
Molecular analysis of cross-resistance to capreomycin, kanamycin, amikacin, and viomycin in Mycobacterium tuberculosis.
mutation of tlyA gene confers resistance to capreomycin and viomycin
Mutation Information
- Protein Change
- Q22*
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- capreomycin|viomycin
- Source Database
- Reslit
2
Tuberculosis drug resistance mutation database.
Mutation Information
tlyA: p.R3*tlyA: p.R14WtlyA: p.K69EtlyA: p.V128EtlyA: p.R18*tlyA: p.P183LtlyA: p.Q22*tlyA: p.Q184*tlyA: p.A67EtlyA: p.F185LtlyA: p.A91EtlyA: p.E238KtlyA: p.L118PtlyA: p.L150PtlyA: p.N236K
- Protein Change
- R3*, R14W, K69E, V128E, R18*, P183L, Q22*, Q184*, A67E, F185L, A91E, E238K, L118P, L150P, N236K
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- Capreomycin
- Source Database
- ResFinder