tonB

TonB protein

Validation StatusCandidate

Overview

Mechanism: required for MccY transport
Validation Method: MIC determination and spot-on-lawn assay
Drug Classes: Cefiderocol, Cephalosporin|Carbapenem
Organisms: Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli, Stenotrophomonas maltophilia
Papers: 3
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	9fs	-	Stenotrophomonas maltophilia	Cephalosporin\|Carbapenem	Reslit	Candidate

Papers3

Mutation in Ton System Genes Confers Resistance to MccY in Salmonella Typhimurium

PMID 36453909 · 2023

Deletion of tonB, exbB, or exbD genes in Salmonella enterica subsp. enterica serovar Typhimurium leads to resistance against Microcin Y (MccY).

Gene Information

Gene Name: tonB
Allele: tonB
Encodes: TonB protein
Source Database: Reslit
Mechanism: required for MccY transport
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Typhimurium
Validation Method: MIC determination and spot-on-lawn assay

Genomic Modification of TonB and Emergence of Small-Colony Phenotype in VIM- and NDM-Producing Escherichia coli following Cefiderocol Exposure In Vitro.

PMID 37022155 · 2023

The study identifies mutations in the tonB gene and hem genes associated with cefiderocol resistance in VIM- and NDM-producing Escherichia coli. These mutations contribute to the emergence of small-colony variants, which are linked to reduced susceptibility to antibiotics.

Gene Information

Gene Name: tonB
Allele: tonB
Encodes: protein involved in iron transport
Source Database: Reslit
Mechanism: insertion of transposable elements (IS 4, IS 6, and IS 26 family)
Confers Resistance To: Cefiderocol
Organisms Tested In: • Escherichia coli
Validation Method: whole-genome sequencing
Sequence Accession: PRJNA750050|PRJNA822923|PRJNA925002

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tonB

Mutations

Gene Information

Gene Information