topA

Topoisomerase I

Validation StatusSupported

Overview

Mechanism: mutation
Validation Method: positive selection analysis
Drug Classes: Quinolone, Kanamycin
Organisms: Pseudomonas aeruginosa, Streptococcus pneumoniae, Mycoplasma pneumoniae, Escherichia coli
Geographic Location: China
Papers: 4
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S180L	-	reduces its activity	Escherichia coli	Kanamycin	Reslit	Candidate

Papers4

Evolutionary Genomics of Niche-Specific Adaptation to the Cystic Fibrosis Lung in Pseudomonas aeruginosa.

PMID 32898270 · 2021

The study identifies genes under positive selection in Pseudomonas aeruginosa strains isolated from the cystic fibrosis (CF) lung, highlighting adaptations related to antibiotic resistance, metabolism, and stress response.

Gene Information

Gene Name: topA
Allele: topA
Encodes: Topoisomerase I
Source Database: Reslit
Confers Resistance To: Quinolone
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: positive selection analysis

Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in Streptococcus pneumoniae.

PMID 37958782 · 2023

The study identifies a mutation in the topA gene (R102A) that reduces the activity of DNA topoisomerase I and increases resistance to Seconeolitsine in Streptococcus pneumoniae.

Gene Information

Gene Name: topA
Allele: topA
Encodes: DNA topoisomerase I
Source Database: Reslit
Organisms Tested In: • Streptococcus pneumoniae
Validation Method: overexpression and enzymatic activity assay

Genomic epidemiological analysis reveals new insights into the resurgence of Mycoplasma pneumoniae in China.

PMID 41278482 · 2025

The study identifies the A2063G mutation in the 23S rRNA gene as a key determinant of macrolide resistance in Mycoplasma pneumoniae strains in Beijing. Additionally, various mutations in genes associated with genome stability, transcription, translation, and virulence were found to be prevalent in Asian strains.

Gene Information

Gene Name: topA
Allele: topA
Encodes: DNA topoisomerase
Source Database: Reslit
Mechanism: mutation
Organisms Tested In: • Mycoplasma pneumoniae
Geographic Location: China
Validation Method: genomic analysis
Sequence Accession: NC_000912.1|NZ_CP010546.1

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