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ResLit

trkA

K+ uptake protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to trkA

AMR Rules

Browse AMR rules for trkA

Validation StatusSupported

Overview

Mechanism: Increases MIC in multiple antibiotics
Validation Method: construction of isogenic mutant and complementation analysis
Drug Classes: Polymyxin b, Piperacillin, Doxycycline, Tetracycline, Nalidixic acid, Gentamicin, Vancomycin
Organisms: Vibrio vulnificus, Escherichia coli, Staphylococcus aureus JE2, Clostridioides difficile
Alleles: 2
Papers: 5
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Q26*	-	-	Clostridioides difficile	Vancomycin	Reslit	Candidate

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession

Papers5

A K+ Uptake Protein, TrkA, Is Required for Serum, Protamine, and Polymyxin B Resistance in Vibrio vulnificus.

PMID 14742502 · 2004

The study identifies TrkA as a K+ uptake protein required for resistance to serum, protamine, and polymyxin B in Vibrio vulnificus. Mutants lacking trkA show reduced resistance to these agents.

Gene Information

Gene Name: trkA
Allele: trkA
Encodes: K+ uptake protein
Source Database: Reslit
Confers Resistance To: Polymyxin b
Organisms Tested In: • Vibrio vulnificus
Validation Method: construction of isogenic mutant and complementation analysis
Sequence Accession: AY293743

Genetic architecture of intrinsic antibiotic susceptibility.

PMID 19462005 · 2009

The study identifies multiple genes and mutations that contribute to antibiotic tolerance in E. coli, revealing a large mutational target size for increasing drug resistance. Key findings include the role of genes involved in electron transport, flagella synthesis, and efflux pumps in modulating susceptibility to various antibiotics.

Gene Information

Gene Name: trkA
Allele: trkA
Encodes: Potassium transporter
Source Database: Reslit
Mechanism: Increases MIC in multiple antibiotics
Confers Resistance To: PiperacillinDoxycyclineTetracyclineNalidixic acid
Organisms Tested In: • Escherichia coli
Validation Method: Transposon insertion analysis

Antimicrobial Peptides and Their Mechanisms of Action Against Pathogens

PMID 24367355

Gene Information

Gene Name: trkA
Allele: TrkA
Encodes: potassium transport protein
Source Database: Reslit
Mechanism: cation transport
Organisms Tested In: • Vibrio vulnificus
Validation Method: TrkA in Vibrio vulnificus is required for CAMP resistance

Genome-Wide Identification of Antimicrobial Intrinsic Resistance Determinants in Staphylococcus aureus.

PMID 28066345 · 2016

The study identifies multiple intrinsic resistance determinants in Staphylococcus aureus, including genes such as atpA, rpsT, vraG, and mecA, which contribute to resistance against various antimicrobial agents. These findings highlight potential targets for developing antimicrobial potentiators.

Gene Information

Gene Name: trkA
Allele: trkA
Encodes: Potassium transporter
Source Database: Reslit
Mechanism: Membrane potential regulation
Confers Resistance To: Gentamicin
Organisms Tested In: • Staphylococcus aureus JE2
Validation Method: E-test

trkA	Reslit	3	Polymyxin b, Piperacillin +4	Vibrio vulnificus +2	-	2004, 2009, 2016	AY293743	-
TrkA	Reslit	1	-	Vibrio vulnificus	-	-	-	-