tuf1

elongation factor Tu1

Validation StatusCandidate

Overview

Validation Method: band-shift assays and in vitro translation experiments
Drug Classes: Kirromycin, Amikacin
Organisms: Planobispora rosea, Streptomyces coelicolor, Pseudomonas aeruginosa
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V21L	-	-	Pseudomonas aeruginosa	Amikacin	Reslit	Candidate

Papers2

Elongation Factor Tu1 of the antibiotic GE2270A producer Planobispora rosea has an unexpected resistance profile against EF-Tu targeted antibiotics.

PMID 9016775 · 1997

The study identified that EF-Tu1 from Planobispora rosea is resistant to GE2270A and kirromycin, with unique amino acid substitutions contributing to this resistance.

Gene Information

Gene Name: tuf1
Allele: tuf1
Encodes: elongation factor Tu1
Source Database: Reslit
Confers Resistance To: Kirromycin
Organisms Tested In: • Planobispora rosea
• Streptomyces coelicolor
Validation Method: band-shift assays and in vitro translation experiments

Browse AMR Genes

tuf1

Mutations

Gene Information