Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

ubiA

decaprenylphosphoryl-5-phospho-beta-D-ribose synthase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to ubiA

AMR Rules

Browse AMR rules for ubiA

Validation StatusSupported

Overview

Mechanism: mutation in the gene leads to resistance to ethambutol
Validation Method: growth and viability assays
Drug Classes: Ethambutol
Organisms: Corynebacterium glutamicum, Mycobacterium tuberculosis, Mycobacterium bovis
Geographic Location: Belarus|South Africa|South Korea|India, China, Egypt|France|Algeria|South Africa, Moldova|global
Papers: 9
Databases: Reslit
Mutations: 21

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
E149D	-	-	Mycobacterium bovis	Ethambutol	Reslit	Candidate
A237V	-	single resistance variant	Mycobacterium tuberculosis	Ethambutol	Card DatabaseReslit	Confirmed
W175G	-	-	Mycobacterium tuberculosis

Papers9

Benzothiazinones mediate killing of Corynebacterineae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesis.

PMID 24446451 · 2014

Overexpression of NCgl2203 (uppS) in Corynebacterium glutamicum increases resistance to BTZ043 by enhancing decaprenyl phosphate synthesis, counteracting the drug's mechanism of action.

Gene Information

Gene Name: ubiA
Allele: ubiA
Encodes: decaprenylphosphoryl-5-phospho-beta-D-ribose synthase
Source Database: Reslit
Organisms Tested In: • Corynebacterium glutamicum
Validation Method: growth and viability assays

Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance.

PMID 30333483 · 2018

The study identifies 33 known AMR genes and 24 new genetic signatures of AMR in Mycobacterium tuberculosis using machine learning and structural analysis. It also reveals 97 epistatic interactions across 10 resistance classes and provides mechanistic insights into the selection of these genes.

Gene Information

Gene Name: ubiA
Allele: ubiA
Encodes: undecaprenyl diphosphate phosphatase
Source Database: Reslit
Mechanism: mutation in the gene leads to resistance to ethambutol
Confers Resistance To: Ethambutol
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Belarus|South Africa|South Korea|India
Validation Method: machine learning and structural analysis

Characterization of Fluoroquinolone-Resistant and Multidrug-Resistant Mycobacterium tuberculosis Isolates Using Whole-Genome Sequencing in Tianjin, China.

PMID 35444430 · 2022

The study characterized various AMR genes and mutations in fluoroquinolone-resistant and multidrug-resistant Mycobacterium tuberculosis isolates using whole-genome sequencing, identifying key resistance mechanisms for several antibiotics.

Gene Information

Gene Name: ubiA
Allele: ubiA
Encodes: ubiquinone biosynthesis protein
Source Database: Reslit
Confers Resistance To: Ethambutol
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: China
Validation Method: whole-genome sequencing

Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing.

PMID 39487429 · 2024

The study identified multiple AMR genes and mutations in Mycobacterium bovis isolates, including resistance to isoniazid, streptomycin, ethambutol, fluoroquinolones, pyrazinamide, d-cycloserine, rifampin, delamanid, and para-aminosalicylic acid.

Gene Information

Gene Name: ubiA
Allele: ubiA
Encodes: ubiquinone biosynthesis protein
Source Database: Reslit
Mechanism: ethambutol resistance
Confers Resistance To: Ethambutol
Organisms Tested In: • Mycobacterium bovis
Geographic Location: Egypt|France|Algeria|South Africa
Validation Method: genomic sequencing and mutation analysis
Sequence Accession: SAMN37519983|SAMN37519961|SAMN37519964|SAMN38024412|SAMN37519969|PRJNA1019495

Evaluating selection at intermediate scales within genes provides robust identification of genes under positive selection in M. tuberculosis clinical isolates.

PMID 41033137 · 2025

The study identifies genes under positive selection in M. tuberculosis clinical isolates, including several known drug-resistance genes such as rpoB, gyrA, gidB, pncA, embB, and ubiA. It highlights the importance of analyzing selection at intermediate scales within genes for accurate identification of resistance-associated genes.

Gene Information

Gene Name: ubiA
Allele: ubiA
Encodes: arabinogalactan synthesis pathway protein
Source Database: Reslit
Mechanism: target of ethambutol
Confers Resistance To: Ethambutol
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Moldova|global
Validation Method: positive selection analysis