uhpB

kinase of the two-component response regulator (UhpA) required for uhpT expression

Validation StatusCandidate

Overview

Mechanism: premature STOP codon
Validation Method: whole-genome sequencing
Drug Classes: Fosfomycin
Organisms: Klebsiella pneumoniae, Escherichia coli
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G469R	-	disruption of G6P-mediated induction of uhpT expression	Escherichia coli	Fosfomycin	Reslit	Candidate
L255*	-	-	-	Fosfomycin	Reslit	Candidate

Papers3

Oral fosfomycin activity against Klebsiella pneumoniae in a dynamic bladder infection in vitro model.

PMID 35211736 · 2022

The study identifies uhpB mutations, including premature stop codons, as a mechanism of fosfomycin resistance in Klebsiella pneumoniae. These mutations impair fosfomycin uptake by disrupting the uhpT transporter.

Gene Information

Gene Name: uhpB
Allele: uhpB
Encodes: kinase of the two-component response regulator (UhpA) required for uhpT expression
Source Database: Reslit
Mechanism: premature STOP codon
Confers Resistance To: Fosfomycin
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: whole-genome sequencing
Sequence Accession: PRJNA701073

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uhpB

Mutations

Gene Information