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Explore antimicrobial resistance genes from the literature
Undecaprenyl pyrophosphate synthase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| K101E | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession |
|---|
| Protein Accession |
|---|
| upps | Reslit | 1 | Vancomycin | Staphylococcus aureus | Taiwan | 2018 | - | - |
| uppS | Reslit | 1 | - | Acinetobacter baumannii | - | 2023 | - | - |
Novel single-nucleotide variations associated with vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
Three novel SNVs in htrA, upps, and fmtC genes are associated with vancomycin resistance in VISA and hVISA isolates.
Genetic synergy in Acinetobacter baumannii undecaprenyl biosynthesis and maintenance of lipid asymmetry impacts outer membrane and antimicrobial resistance.
The study identifies that the uppS gene, encoding undecaprenyl pyrophosphate synthase, synergizes with the Mla system in Acinetobacter baumannii to promote resistance to membrane stress and antibiotics.
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