vacJ

lipoprotein of the Mla pathway

Validation StatusCandidate

Overview

Mechanism: loss of function
Validation Method: overexpression analysis
Drug Classes: Colistin, Polymyxin b
Organisms: Acinetobacter baumannii, Vibrio cholerae O139 MO10, A. baumannii
Geographic Location: Global, Pakistan|Taiwan|Germany|Spain|Korea|Thailand|Dubai|India|Italy|Czech Republic|China|Brazil|Australia
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R166N	-	-	A. baumannii	Colistin	Reslit	Candidate
Q249T	-	-	A. baumannii	Colistin	Reslit	Candidate

Papers3

Antimicrobial Resistance in Multidrug-Resistant Pathogens: Focus on Polymyxin Resistance Mechanisms

PMID 32784516 · 2023

This review discusses the antibacterial activity and mechanisms of resistance to polymyxins, focusing on their interaction with bacterial membranes and the genetic basis of resistance.

Gene Information

Gene Name: vacJ
Allele: vacJ
Source Database: Reslit
Confers Resistance To: Colistin
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Pakistan|Taiwan|Germany|Spain|Korea|Thailand|Dubai|India|Italy|Czech Republic|China|Brazil|Australia
Validation Method: overexpression analysis

Mechanisms of Polymyxin B Resistance in Vibrio cholerae Variants Through Membrane Vesicle Production and Genetic Mutations

PMID 36090081 · 2023

Mutations in vacJ, mlaF, dacB, and ihfA contribute to polymyxin B resistance in Vibrio cholerae variants through hypervesiculation and membrane remodeling.

Gene Information

Gene Name: vacJ
Allele: vacJ
Encodes: lipoprotein of the Mla pathway
Source Database: Reslit
Mechanism: loss of function
Confers Resistance To: Polymyxin b
Organisms Tested In: • Vibrio cholerae O139 MO10
Geographic Location: Global
Validation Method: genomic sequencing and complementation assay
Sequence Accession: NCBI Accession Number 1|NCBI Accession Number 2

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vacJ

Mutations

Gene Information

Gene Information