vanA
glycopeptide resistance
Overview
- Drug Classes
- vancomycin, teicoplanin
- Organisms
- Enterococcus faecium, Enterococcus faecium BM4147, Enterococcus faecalis +7 more
- Papers
- 12
vanA and vanB incorporate into an endemic ampicillin-resistant vancomycin-sensitive Enterococcus faecium strain: effect on interpretation of clonality.
PMID 10565910 · 1999The study characterizes the incorporation of vanA and vanB genes into an endemic ampicillin-resistant vancomycin-sensitive Enterococcus faecium strain, highlighting their role in vancomycin resistance.
Gene Information
- Gene Name
- vanA
- Allele
- VanA
- Encodes
- glycopeptide resistance
- Validation Method
- multiplex PCR and hybridization with vanA probe
Confers Resistance To
Organisms Tested In
Isolation Details
The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA).
PMID 10908650 · 2000The study elucidates the molecular basis of vancomycin resistance in Enterococci by characterizing the crystal structure of VanA, a d-alanyl-d-lactate ligase that plays a critical role in the biosynthesis of cell-wall precursors resistant to vancomycin.
Gene Information
- Gene Name
- vanA
- Allele
- VanA
- Encodes
- d-alanyl-d-lactate ligase
- Validation Method
- crystal structure determination and enzymatic activity analysis
Mechanism
biosynthesis of alternate cell-wall precursors
Confers Resistance To
Organisms Tested In
Enterococcus faecalis resistant to vancomycin and teicoplanin (VanA phenotype) isolated from a bone marrow transplanted patient in Brazil.
PMID 11290314 · 2001The study reports the first case of Enterococcus faecalis with the VanA phenotype resistant to vancomycin and teicoplanin in Brazil.
Gene Information
- Gene Name
- vanA
- Allele
- VanA
- Encodes
- glycopeptide resistance
- Validation Method
- PCR and Etest
Confers Resistance To
Organisms Tested In
Isolation Details
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
PMID 11585788 · 2023The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Gene Information
- Gene Name
- vanA
- Allele
- VanA
- Encodes
- d-Ala-d-Ala ligase
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
Excretion of vancomycin-resistant enterococci by wild mammals.
PMID 12023924 · 2002Vancomycin-resistant Enterococcus faecium (VRE) were found in wild mammals, specifically woodmice and badgers, with the vanA gene being responsible for vancomycin resistance.
Gene Information
- Gene Name
- vanA
- Allele
- VanA
- Encodes
- glycopeptide resistance
- Validation Method
- PCR and MIC testing
Confers Resistance To
Organisms Tested In
Isolation Details
Impact of elements containing glycopeptide resistance genes on expression of virulence in Enterococcus faecalis peritonitis: a pilot study with rats.
PMID 12709322 · 2003The study investigated the impact of glycopeptide resistance genes vanA and vanB on the virulence of Enterococcus faecalis in a rat peritonitis model. Both vanA and vanB conferred resistance to vancomycin.
Gene Information
- Gene Name
- vanA
- Allele
- VanA
- Encodes
- glycopeptide resistance
- Validation Method
- susceptibility testing
Confers Resistance To
Organisms Tested In
Presence of a vanA-carrying pheromone response plasmid (pBRG1) in a clinical isolate of Enterococcus faecium.
PMID 12709324 · 2003The study identified a vanA-carrying pheromone response plasmid (pBRG1) in a clinical isolate of Enterococcus faecium, which confers high-level resistance to vancomycin and teicoplanin.
Gene Information
- Gene Name
- vanA
- Allele
- VanA
- Encodes
- glycopeptide resistance determinant
- Validation Method
- plasmid analysis and hybridization
Confers Resistance To
Organisms Tested In
Highly Conjugative pMG1-Like Plasmids Carrying Tn1546-Like Transposons That Encode Vancomycin Resistance in Enterococcus faecium.
PMID 14617670 · 2003The study identifies vanA and Tn1546 as responsible for vancomycin resistance in Enterococcus faecium, highlighting their role in the dissemination of resistance through conjugative plasmids.
Gene Information
- Gene Name
- vanA
- Allele
- VanA
- Encodes
- glycopeptide resistance determinant
- Validation Method
- PCR analysis and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
Vancomycin-resistant Staphylococcus aureus isolate from a patient in Pennsylvania.
PMID 14693550 · 2004The study reports the second VRSA isolate in the United States, which contains the vanA gene responsible for vancomycin resistance and other resistance genes such as mecA, erm(A), and aac(6')-aph(2").
Gene Information
- Gene Name
- vanA
- Allele
- VanA
- Encodes
- glycopeptide resistance determinant
- Validation Method
- PCR and DNA sequence analysis
Confers Resistance To
Organisms Tested In
Isolation Details
Persistence of animal and human glycopeptide-resistant enterococci on two Norwegian poultry farms formerly exposed to avoparcin is associated with a widespread plasmid-mediated vanA element within a polyclonal enterococcus faecium population.
PMID 15640183 · 2005The study identified a plasmid-mediated vanA element associated with glycopeptide-resistant Enterococcus faecium on Norwegian poultry farms, highlighting the persistence of resistance despite the ban on avoparcin.
Gene Information
- Gene Name
- vanA
- Allele
- VanA
- Encodes
- glycopeptide resistance
- Validation Method
- PCR and hybridization analyses
Confers Resistance To
Organisms Tested In
Isolation Details
First nosocomial outbreak of vancomycin-resistant Enterococcus faecium expressing a VanD-like phenotype associated with a vanA genotype.
PMID 16081891 · 2005Gene Information
- Gene Name
- vanA
- Allele
- VanA
- Encodes
- glycopeptide resistance
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.
PMID 16189102 · 2005The study identifies vanA operons in Paenibacillus strains that confer resistance to glycopeptide antibiotics such as vancomycin and teicoplanin. These operons show similarities to those found in enterococci.
Gene Information
- Gene Name
- vanA
- Allele
- VanA
- Encodes
- glycopeptide resistance
- Validation Method
- sequence analysis and enzymatic activity assays
Confers Resistance To
Organisms Tested In
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