vanC
d-Ala-d-Ser ligase
Overview
- Drug Classes
- vancomycin
- Organisms
- Enterococcus casseliflavus, Enterococcus flavescens, Enterococcus casseliflavus ATCC 25788
- Alleles
- 2
- Papers
- 2
| Allele | Papers | Drug Classes | Organisms | Countries | Years | Status |
|---|---|---|---|---|---|---|
| vanC-2 | 2 | vancomycin | Enterococcus casseliflavus +1 | Europe|North America|Asia | 2002, 2023 | Not Validated |
| vanC-3 | 1 | vancomycin | Enterococcus flavescens | Europe|North America|Asia | 2023 | Not Validated |
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
PMID 11585788 · 2023The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Gene Information
- Gene Name
- vanC
- Allele
- vanC-2
- Encodes
- d-Ala-d-Ser ligase
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
PMID 11585788 · 2023The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Gene Information
- Gene Name
- vanC
- Allele
- vanC-3
- Encodes
- d-Ala-d-Ser ligase
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
Biochemical and genetic characterization of the vanC-2 vancomycin resistance gene cluster of Enterococcus casseliflavus ATCC 25788.
PMID 12234834 · 2002The study characterizes the vanC-2 gene cluster in Enterococcus casseliflavus ATCC 25788, identifying genes involved in vancomycin resistance, including vanC-2, vanXY C-2, vanT C-2, vanR C-2, and vanS C-2. These genes contribute to the production of cell wall precursors that replace d-alanine with d-serine, reducing vancomycin binding.
Gene Information
- Gene Name
- vanC
- Allele
- vanC-2
- Encodes
- d-Ala-d-Ser ligase
- Validation Method
- cloning and enzymatic activity assays
Confers Resistance To
Organisms Tested In
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