vanC1
ligase
Overview
- Drug Classes
- glycopeptides, vancomycin
- Organisms
- Enterococcus gallinarum BM4174, Escherichia coli, Enterococcus gallinarum
- Papers
- 3
vanC cluster of vancomycin-resistant Enterococcus gallinarum BM4174.
PMID 10817725 · 2000The study identifies the vanC cluster in Enterococcus gallinarum BM4174, consisting of vanC-1, vanXY_C, vanT, vanR_C, and vanS_C. The genes vanC-1, vanXY_C, and vanT are necessary and sufficient for vancomycin resistance.
Gene Information
- Gene Name
- vanC1
- Allele
- vanC-1
- Encodes
- ligase
- Validation Method
- cloning and MIC testing
Mechanism
synthesizes the dipeptide d-Ala-d-Ser for addition to UDP-MurNAc-tripeptide
Confers Resistance To
Organisms Tested In
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
PMID 11585788 · 2023The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Gene Information
- Gene Name
- vanC1
- Allele
- vanC-1
- Encodes
- d-Ala-d-Ser ligase
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
Transcriptional analysis of the vanC cluster from Enterococcus gallinarum strains with constitutive and inducible vancomycin resistance.
PMID 15728903 · 2005The study characterizes the vanC cluster in Enterococcus gallinarum strains with constitutive and inducible vancomycin resistance, identifying key genes and mutations involved in glycopeptide resistance mechanisms.
Gene Information
- Gene Name
- vanC1
- Allele
- vanC-1
- Encodes
- protein involved in the synthesis of d-Ser and its incorporation into the growing peptidoglycan chain
- Validation Method
- transcriptional analysis and sequence comparison
Confers Resistance To
Organisms Tested In
Isolation Details
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