Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R322M | - | The R322M mutation decreases the use of D-serine and broadens the specificity for other D-amino acids. | Enterococcus casseliflavus, Escherichia coli | Vancomycin | Reslit | Candidate |
| F250Y | - | The F250Y mutation decreases the use of D-serine and broadens the specificity for other D-amino acids. | Escherichia coli, Enterococcus casseliflavus | Vancomycin | Reslit | Candidate |
| L282R | - | The L282R mutation increases the preference for D-serine over D-alanine. | Enterococcus casseliflavus, Escherichia coli |
Vancomycin |
Reslit |
| Candidate |
Active-site mutants of the VanC2 D-alanyl-D-serine ligase, characteristic of one vancomycin-resistant bacterial phenotype, revert towards wild-type D-alanyl-D-alanine ligases.
Mutants exhibit altered substrate specificity and reduced vancomycin resistance
© 2026 ResLit. Data sourced from PubMed literature analysis.
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