Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ligase
Overview
Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.
The study characterizes the vanD glycopeptide resistance gene cluster in Enterococcus faecium BM4339, identifying several genes including vanD, vanH, vanX, vanY, vanR, and vanS, which collectively confer resistance to glycopeptide antibiotics through the synthesis of d-alanyl-d-lactate-terminating peptidoglycan precursors.
Molecular characterization of the vanD gene cluster and a novel insertion element in a vancomycin-resistant enterococcus isolated in Canada.
The study characterizes the vanD gene cluster and a novel insertion element, IS_Efm1, in a vancomycin-resistant Enterococcus faecium strain isolated in Canada. The vanD operon is constitutively expressed, and IS_Efm1 interrupts the ddl gene, affecting d-Ala-d-Ala ligase activity.
VanD-Type Vancomycin-Resistant Enterococcus faecium 10/96A.
The study identifies the vanD gene cluster in Enterococcus faecium 10/96A, which confers vancomycin resistance through the synthesis of peptidoglycan precursors ending in d-Ala-d-Lac. A G184S mutation in the ddl gene impairs the d-Ala:d-Ala ligase, contributing to resistance.
No comments yet. Be the first to comment!
© 2026 ResLit. Data sourced from PubMed literature analysis.
Built for antimicrobial resistance research