vanE
glycopeptide resistance
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to vanE
AMR Rules
Browse AMR rules for vanE
Validation StatusCandidate
Overview
- Mechanism
- synthesis of peptidoglycan precursors that terminate in d-Ala-d-Ser
- Validation Method
- PCR, sequencing, and biochemical analysis
- Drug Classes
- vancomycin
- Organisms
- Enterococcus faecalis BM4405, Enterococcus faecalis N00-410
- Geographic Location
- Canada
- Papers
- 2
- Databases
- Reslit
Papers2
1
VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405.
The study identifies VanE, a new acquired glycopeptide resistance gene in Enterococcus faecalis BM4405, which confers resistance to vancomycin through the synthesis of peptidoglycan precursors ending in d-Ala-d-Ser.
Gene Information
- Gene Name
- vanE
- Allele
- VanE
- Encodes
- glycopeptide resistance
- Source Database
- Reslit
- Mechanism
- synthesis of peptidoglycan precursors that terminate in d-Ala-d-Ser
- Confers Resistance To
- vancomycin
- Organisms Tested In
- • Enterococcus faecalis BM4405
- Validation Method
- PCR, sequencing, and biochemical analysis
- Sequence Accession
- AF136925
2
Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada.
The vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 was characterized, revealing a low-level vancomycin resistance mechanism through alteration of peptidoglycan precursors.
Gene Information
- Gene Name
- vanE
- Allele
- VanE
- Encodes
- d-Ala-d-Ser ligase
- Source Database
- Reslit
- Mechanism
- confers low-level vancomycin resistance by altering peptidoglycan precursor termini
- Confers Resistance To
- vancomycin
- Organisms Tested In
- • Enterococcus faecalis N00-410
- Geographic Location
- Canada
- Validation Method
- sequence analysis and comparison with vanC1 operon
- Sequence Accession
- AF430807
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