vanH
dehydrogenase
Overview
- Mechanism
- constitutive synthesis of peptidoglycan precursors terminating in d-alanyl-d-lactate
- Validation Method
- cloning and MIC testing
- Drug Classes
- glycopeptides, vancomycin
- Organisms
- Enterococcus faecium BM4339, Enterococcus faecium 10/96A
- Papers
- 2
- Databases
- Reslit
Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.
The study characterizes the vanD glycopeptide resistance gene cluster in Enterococcus faecium BM4339, identifying several genes including vanD, vanH, vanX, vanY, vanR, and vanS, which collectively confer resistance to glycopeptide antibiotics through the synthesis of d-alanyl-d-lactate-terminating peptidoglycan precursors.
Gene Information
- Gene Name
- vanH
- Allele
- VanH
- Encodes
- dehydrogenase
- Source Database
- Reslit
- Confers Resistance To
- glycopeptides
- Organisms Tested In
- • Enterococcus faecium BM4339
- Validation Method
- cloning and MIC testing
- Sequence Accession
- AF130997|AF130998
VanD-Type Vancomycin-Resistant Enterococcus faecium 10/96A.
The study identifies the vanD gene cluster in Enterococcus faecium 10/96A, which confers vancomycin resistance through the synthesis of peptidoglycan precursors ending in d-Ala-d-Lac. A G184S mutation in the ddl gene impairs the d-Ala:d-Ala ligase, contributing to resistance.
Gene Information
- Gene Name
- vanH
- Allele
- VanH
- Encodes
- dehydrogenase
- Source Database
- Reslit
- Mechanism
- constitutive synthesis of peptidoglycan precursors terminating in d-alanyl-d-lactate
- Confers Resistance To
- vancomycin
- Organisms Tested In
- • Enterococcus faecium 10/96A
- Validation Method
- cloning and MIC testing
- Sequence Accession
- AY082011
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