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Explore antimicrobial resistance genes from the literature

ResLit

vanH-B

D-lactate dehydrogenase VanH-B

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to vanH-B

AMR Rules

Browse AMR rules for vanH-B

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Validation Method: metagenomic analysis
Drug Classes: VANCOMYCIN, Vancomycin
Organisms: Enterococcus faecalis, Enterococcus faecium, Swine, Escherichia coli
Geographic Location: China|United States|United Kingdom|Europe, Europe
Alleles: 2
Papers: 7
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
VanH-B	Card DatabaseReference Gene CatalogReslit	7	VANCOMYCIN, Vancomycin	Enterococcus faecalis +2	China\|United States\|United Kingdom\|Europe	1996, 2000, 2001, 2009, 2022	AF192329.1

Papers7

Characterization of transposon Tn1549, conferring VanB-type resistance in Enterococcus spp.

PMID 10846226 · 2000

Gene Information

Gene Name: vanH-B
Allele: VanH-B
Encodes: D-lactate dehydrogenase VanH-B
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: AF192329.1
Protein Accession: AAF72362.1

High prevalence of VanB2 vancomycin-resistant Enterococcus faecium in Taiwan.

PMID 11376048 · 2001

Gene Information

Gene Name: vanH-B
Allele: VanH-B
Encodes: D-lactate dehydrogenase VanH-B
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AF310956.2
Protein Accession: AAG34690.1

Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2201, encoding erythromycin resistance and cytolysin (Hly/Bac).

PMID 19029325 · 2009

Gene Information

Gene Name: vanH-B
Allele: VanH-B
Encodes: D-lactate dehydrogenase VanH-B
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: AB374546.1
Protein Accession: BAH02342.1

VanB-type Enterococcus faecium clinical isolate successively inducibly resistant to, dependent on, and constitutively resistant to vancomycin.

PMID 19273676 · 2009

Gene Information

Gene Name: vanH-B
Allele: VanH-B
Encodes: D-lactate dehydrogenase VanH-B
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: FJ767776.1
Protein Accession: ACQ66104.1

Resistome Analysis of Global Livestock and Soil Microbiomes.

PMID 35875563 · 2022

The study identified numerous antimicrobial resistance genes (ARGs) in livestock and soil microbiomes, including tetracycline resistance genes (tet(W)_1, tet(Q)_1, tet(O)_1, tet(44)_1), macrolide resistance gene (ole(B)_1), colistin resistance genes (mcr-1.11, mcr-5.1, mcr-7.1), and vancomycin resistance genes (vanG, vanA-B, vanH-B, vanXY-G).

Gene Information

Gene Name: vanH-B
Allele: VanH-B
Encodes: vancomycin resistance
Source Database: Reslit
Confers Resistance To: Vancomycin
Organisms Tested In: • Swine
Geographic Location: China|United States|United Kingdom|Europe
Validation Method: metagenomic analysis

Occurrence and Drivers of Antibiotic Resistance Genes Carried by Bacteriophages in Soils Following Different Fertilization Treatments.

PMID 40559968 · 2025

The study identified 19 pARG subtypes in soils with different fertilization treatments, highlighting the impact of organic fertilizers on the diversity and abundance of antibiotic resistance genes carried by bacteriophages.

Gene Information

Gene Name: vanH-B
Allele: vanHB
Encodes: glycopeptide resistance determinant
Source Database: Reslit
Confers Resistance To: Vancomycin
Organisms Tested In: • Escherichia coli
Geographic Location: Europe
Validation Method: droplet digital PCR

Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583.

PMID 8631706 · 1996

Gene Information

Gene Name: vanH-B
Allele: VanH-B
Encodes: D-lactate dehydrogenase VanH-B
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: U35369.1
Protein Accession: AAB05626.1
Notes: ARO:3002943

Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583.

PMID 8631706 · 1996

Gene Information

Gene Name: vanH-B
Allele: VanH-B
Encodes: D-lactate dehydrogenase VanH-B
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: U35369.1
Protein Accession: AAB05626.1
Notes: ARO:3002943