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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse GenesvanH-D

vanH-D

D-lactate dehydrogenase VanH-D

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to vanH-D

Browse AMR rules for vanH-D

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Drug Classes: VANCOMYCIN
Organisms: Enterococcus faecium, Enterococcus gallinarum, Enterococcus raffinosus
Papers: 7
Databases: Card DatabaseReference Gene Catalog

Papers7

1

Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.

PMID 10368136 · 1999

Gene Information

Gene Name: vanH-D
Allele: VanH-D
Encodes: D-lactate dehydrogenase VanH-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AF130997.1
Protein Accession: AAD42183.1

2

A cluster of VanD vancomycin-resistant Enterococcus faecium: molecular characterization and clinical epidemiology.

PMID 10479146 · 1999

Gene Information

Gene Name: vanH-D
Allele: VanH-D
Encodes: D-lactate dehydrogenase VanH-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AF153050.1
Protein Accession: AAD41881.1

3

Molecular characterization of the vanD gene cluster and a novel insertion element in a vancomycin-resistant enterococcus isolated in Canada.

PMID 10835012 · 2000

Gene Information

Gene Name: vanH-D
Allele: VanH-D
Encodes: D-lactate dehydrogenase VanH-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AF175293.1
Protein Accession: AAD51059.1

4

Characterization of a divergent vanD-type resistance element from the first glycopeptide-resistant strain of Enterococcus faecium isolated in Brazil.

PMID 11083656 · 2000

Gene Information

Gene Name: vanH-D
Allele: VanH-D
Encodes: D-lactate dehydrogenase VanH-D
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AF277571.1
Protein Accession: AAG37025.1
Notes: ARO:3002944

5

Characterization of a divergent vanD-type resistance element from the first glycopeptide-resistant strain of Enterococcus faecium isolated in Brazil.

PMID 11083656 · 2000

Gene Information

Gene Name: vanH-D
Allele: VanH-D
Encodes: D-lactate dehydrogenase VanH-D
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AF277571.1
Protein Accession: AAG37025.1
Notes: ARO:3002944

6

Enterococcus faecium N03-0072 carries a new VanD-type vancomycin resistance determinant: characterization of the VanD5 operon.

PMID 15308604 · 2004

Gene Information

Gene Name: vanH-D
Allele: VanH-D
Encodes: D-lactate dehydrogenase VanH-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AY489045.1
Protein Accession: AAR37059.1

7

Enterococcus gallinarum N04-0414 harbors a VanD-type vancomycin resistance operon and does not contain a D-alanine:D-alanine 2 (ddl2) gene.

PMID 16495270 · 2006

Gene Information

Gene Name: vanH-D
Allele: VanH-D
Encodes: D-lactate dehydrogenase VanH-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus gallinarum
Sequence Accession: DQ172830.1
Protein Accession: AAZ98838.1

8

First VanD-Type vancomycin-resistant Enterococcus raffinosus isolate.

PMID 17000737 · 2006

Gene Information

Gene Name: vanH-D
Allele: VanH-D
Encodes: D-lactate dehydrogenase VanH-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus raffinosus
Sequence Accession: AB242319.1
Protein Accession: BAE96116.1

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
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CARD
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AMR Rules

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Curator Login
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© 2026 ResLit. Data sourced from PubMed literature analysis.

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