Browse AMR Genes

Explore antimicrobial resistance genes from the literature

vanH-O

D-lactate dehydrogenase VanH-O

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to vanH-O

Browse AMR rules for vanH-O

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Validation Method: frequently observed in >1,500 strains
Drug Classes: VANCOMYCIN, Glycopeptide, Vancomycin
Organisms: Prescottella equi, Mycobacteroides abscessus complex, Staphylococcus aureus
Geographic Location: China
Alleles: 2
Papers: 3
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
VanH-O	Card DatabaseReference Gene Catalog	2	VANCOMYCIN	Prescottella equi	-	2014	KF478993.1	AHA41499.1
vanHO

Papers3

1

vanO, a new glycopeptide resistance operon in environmental Rhodococcus equi isolates.

PMID 24342631 · 2014

Gene Information

Gene Name: vanH-O
Allele: VanH-O
Encodes: D-lactate dehydrogenase VanH-O
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Prescottella equi
Sequence Accession: KF478993.1
Protein Accession: AHA41499.1
Notes: ARO:3002948

2

vanO, a new glycopeptide resistance operon in environmental Rhodococcus equi isolates.

PMID 24342631 · 2014

Gene Information

Gene Name: vanH-O
Allele: VanH-O
Encodes: D-lactate dehydrogenase VanH-O
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Prescottella equi
Sequence Accession: KF478993.1
Protein Accession: AHA41499.1
Notes: ARO:3002948

3

The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.

PMID 36261788 · 2022

The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.

Gene Information

Gene Name: vanH-O
Allele: vanHO
Encodes: vancomycin resistance protein
Source Database: Reslit
Confers Resistance To: Glycopeptide
Organisms Tested In: • Mycobacteroides abscessus complex
Validation Method: frequently observed in >1,500 strains

4

Resistance phenotype and genetic features of a heterogeneous vancomycin intermediate-resistant Staphylococcus aureus strain from an immunocompromised patient.

PMID 38057692 · 2024

The study characterizes a heterogeneous vancomycin intermediate-resistant Staphylococcus aureus (hVISA) strain, identifying multiple mutations in genes associated with vancomycin resistance, including fmtB, mprF, dltA, dltD, lytM, pbp4, sceD, tagA, graR, vraG, vraR, yycH, yycI, mutL, rpoD, sigB, msaC, trpC, and atp.

Gene Information

Gene Name: vanH-O
Allele: vanHO
Encodes: glycopeptide resistance
Source Database: Reslit
Mechanism: unknown
Confers Resistance To: Vancomycin
Organisms Tested In: • Staphylococcus aureus
Geographic Location: China
Validation Method: genomic analysis
Sequence Accession: SRR24457822|SRR24457821|SRR24457820|SRR24457819