Browse AMR Genes

Explore antimicrobial resistance genes from the literature

vanI

d-Ala-d-Lac ligase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to vanI

Browse AMR rules for vanI

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Validation Method: resistance to vancomycin and teicoplanin with MIC values > 150 μg/ml and > 25 μg/ml respectively
Drug Classes: Vancomycin, Teicoplanin, VANCOMYCIN, Glycopeptide
Organisms: Desulfitobacterium hafniense, Desulfitobacterium chlororespirans, Desulfosporosinus spp., Desulfitobacterium hafniense TCP-A, Desulfitobacterium hafniense PCP-1, Desulfitobacterium dichloroeliminans LMG P-21439, Mycobacteroides abscessus complex, Nocardia
Geographic Location: China
Alleles: 2
Papers: 4
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
VanI	Card DatabaseReference Gene CatalogReslit	6	Vancomycin, Teicoplanin +2	Desulfitobacterium hafniense +5	China

Papers4

1

vanI: a novel D-Ala-D-Lac vancomycin resistance gene cluster found in Desulfitobacterium hafniense.

PMID 25042042 · 2014

The study identifies a novel vancomycin resistance gene cluster, vanI, in Desulfitobacterium hafniense and related species, which confers resistance to vancomycin and teicoplanin.

Gene Information

Gene Name: vanI
Allele: VanI
Encodes: d-Ala-d-Lac ligase
Source Database: Reslit
Confers Resistance To: VancomycinTeicoplanin
Organisms Tested In: • Desulfitobacterium hafniense
• Desulfitobacterium chlororespirans
• Desulfosporosinus spp.
Validation Method: resistance to vancomycin and teicoplanin with MIC values > 150 μg/ml and > 25 μg/ml respectively
Sequence Accession: AP008230.1|HQ433581|HQ433580|CP001336.1|HQ433585|HQ433583|HQ433582|HQ433584|HQ433586|2508507521

2

Comparative genomics of the genus Desulfitobacterium.

PMID 29040502 · 2017

Gene Information

Gene Name: vanI
Allele: VanI
Encodes: D-alanine--(R)-lactate ligase VanI
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Desulfitobacterium hafniense TCP-A, Desulfitobacterium hafniense PCP-1, Desulfitobacterium dichloroeliminans LMG P-21439
Sequence Accession: AQZD01000005.1, ARAZ01000048.1, CP003344.1

3

The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.

PMID 36261788 · 2022

The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.

Gene Information

Gene Name: vanI
Allele: VanI
Encodes: vancomycin resistance ligase
Source Database: Reslit
Confers Resistance To: Glycopeptide
Organisms Tested In: • Mycobacteroides abscessus complex
Validation Method: observed in all strains

4

Whole Genome Sequencing Highlights the Pathogenic Profile in Nocardia Keratitis.

PMID 38502137 · 2024

The study identified antibiotic resistance genes (ARGs) in Nocardia strains, revealing resistance to multiple drugs including rifampin and vancomycin. The mce gene family was linked to the pathogenicity and clinical severity of Nocardia keratitis.

Gene Information

Gene Name: vanI
Allele: VanI
Encodes: glycopeptide resistance gene
Source Database: Reslit
Confers Resistance To: Vancomycin
Organisms Tested In: • Nocardia
Geographic Location: China
Validation Method: BLASTp against CARD

5

Gene Information

Gene Name: vanI
Allele: VanI
Encodes: D-alanine--(R)-lactate ligase VanI
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Desulfitobacterium hafniense
Sequence Accession: LOCK01000072.1
Protein Accession: KTE89608.1
Notes: ARO:3003723

6

Gene Information

Gene Name: vanI
Allele: VanI
Encodes: D-alanine--(R)-lactate ligase VanI
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Desulfitobacterium hafniense
Sequence Accession: LOCK01000072.1
Protein Accession: KTE89608.1
Notes: ARO:3003723

7

Gene Information

Gene Name: vanI
Allele: vanI
Encodes: Van ligase;glycopeptide resistance gene cluster
Source Database: Card Database
Mechanism: antibiotic target alteration
Organisms Tested In: • Desulfitobacterium hafniense
Sequence Accession: LOCK01000072.1
Protein Accession: KTE89608.1
Notes: ARO:3003723