Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
two-component system response regulator
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| T115A | - | likely affects the expression of the downstream resistance genes | Clostridioides difficile | vancomycin | Reslit | Supported |
| P216T | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| T69S | - | allows activation independent of VanS | Streptomyces toyocaensis, Streptomyces coelicolor | glycopeptides | Reslit | Candidate |
| M55I | constitutive expression of the vanG operon | Clostridioides difficile | vancomycin | Reslit | Candidate |
Mechanisms of antibiotic resistance of Clostridioides difficile.
Review
Mechanisms and impact of antimicrobial resistance in Clostridioides difficile.
Review
The vanR(Cd) Mutation 343A>G, Resulting in a Thr115Ala Substitution, Is Associated with an Elevated Minimum Inhibitory Concentration (MIC) of Vancomycin in Clostridioides difficile Clinical Isolates from Florida.
Research Article
associated with elevated vancomycin MIC
Staphylococcus aureus VRSA-11B Is a Constitutive Vancomycin-Resistant Mutant of Vancomycin-Dependent VRSA-11A.
Research Article
Mutation in vanR leads to constitutive expression of vanA operon
In Vivo Characterization of the Activation and Interaction of the VanR-VanS Two-Component Regulatory System Controlling Glycopeptide Antibiotic Resistance in Two Related Streptomyces Species.
Research Article
The T69S mutation in the REC domain of VanRst allows activation independent of VanS.
Genetic determinants of resistance to antimicrobial therapeutics are rare in publicly available Clostridioides difficile genome sequences.
Research Article
Detected in 752 genomes
Reference Susceptibility Testing and Genomic Surveillance of Clostridioides difficile, United States, 2012-17.
Research Article
VanG- and D-Ala-D-Ser-dependent peptidoglycan synthesis and vancomycin resistance in Clostridioides difficile.
Research Article
causes constitutive expression of vanG operon