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ResLit

vanR-D

vancomycin resistance response regulator transcription factor VanR-D

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to vanR-D

AMR Rules

Browse AMR rules for vanR-D

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Validation Method: qPCR
Drug Classes: VANCOMYCIN, Vancomycin, Glycopeptide
Organisms: Enterococcus faecium, Enterococcus gallinarum, Enterococcus faecalis, Rothia nasimurium
Geographic Location: China|Xinjiang, North America|Eastern Europe
Alleles: 2
Papers: 8
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
VanR-D	Card DatabaseReference Gene Catalog	7	VANCOMYCIN	Enterococcus faecium +1	-	1999, 2000, 2003, 2004, 2006, 2009	AF130997.1	AAD42180.1

Papers8

Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.

PMID 10368136 · 1999

Gene Information

Gene Name: vanR-D
Allele: VanR-D
Encodes: vancomycin resistance response regulator transcription factor VanR-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AF130997.1
Protein Accession: AAD42180.1

Molecular characterization of the vanD gene cluster and a novel insertion element in a vancomycin-resistant enterococcus isolated in Canada.

PMID 10835012 · 2000

Gene Information

Gene Name: vanR-D
Allele: VanR-D
Encodes: vancomycin resistance response regulator transcription factor VanR-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AF175293.1
Protein Accession: AAD51056.1

VanD-type vancomycin-resistant Enterococcus faecium 10/96A.

PMID 12499162 · 2003

Gene Information

Gene Name: vanR-D
Allele: VanR-D
Encodes: vancomycin resistance response regulator transcription factor VanR-D
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AY082011.1
Protein Accession: AAM09851.1
Notes: ARO:3002923

VanD-type vancomycin-resistant Enterococcus faecium 10/96A.

PMID 12499162 · 2003

Gene Information

Gene Name: vanR-D
Allele: VanR-D
Encodes: vancomycin resistance response regulator transcription factor VanR-D
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AY082011.1
Protein Accession: AAM09851.1
Notes: ARO:3002923

Enterococcus faecium N03-0072 carries a new VanD-type vancomycin resistance determinant: characterization of the VanD5 operon.

PMID 15308604 · 2004

Gene Information

Gene Name: vanR-D
Allele: VanR-D
Encodes: vancomycin resistance response regulator transcription factor VanR-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AY489045.1
Protein Accession: AAR37056.1

Enterococcus gallinarum N04-0414 harbors a VanD-type vancomycin resistance operon and does not contain a D-alanine:D-alanine 2 (ddl2) gene.

PMID 16495270 · 2006

Gene Information

Gene Name: vanR-D
Allele: VanR-D
Encodes: vancomycin resistance response regulator transcription factor VanR-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus gallinarum
Sequence Accession: DQ172830.1
Protein Accession: AAZ98835.1

New combinations of mutations in VanD-Type vancomycin-resistant Enterococcus faecium, Enterococcus faecalis, and Enterococcus avium strains.

PMID 19258279 · 2009

Gene Information

Gene Name: vanR-D
Allele: VanR-D
Encodes: vancomycin resistance response regulator transcription factor VanR-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: EU999036.1
Protein Accession: ACM47283.1

Ribaxamase, an Orally Administered β-Lactamase, Diminishes Changes to Acquired Antimicrobial Resistance of the Gut Resistome in Patients Treated with Ceftriaxone.

PMID 32801790 · 2020

The study identified several β-lactamase and vancomycin resistance genes that were significantly increased in placebo-treated patients compared to ribaxamase-treated patients following ceftriaxone exposure.

Gene Information

Gene Name: vanR-D
Allele: vanRD
Encodes: vancomycin resistance protein
Source Database: Reslit
Confers Resistance To: Vancomycin
Organisms Tested In: • Enterococcus faecalis
Geographic Location: North America|Eastern Europe
Validation Method: qPCR
Sequence Accession: PRJNA589866

Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.

PMID 40148435 · 2025

The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.

Gene Information

Gene Name: vanR-D
Allele: vanRD
Encodes: regulator of glycopeptide resistance
Source Database: Reslit
Confers Resistance To: Glycopeptide
Organisms Tested In: • Rothia nasimurium
Geographic Location: China|Xinjiang
Validation Method: genome sequencing
Sequence Accession: JAYWIX000000000|CP056080