Browse AMR Genes

Explore antimicrobial resistance genes from the literature

vanR-L

vancomycin resistance response regulator transcription factor VanR-L

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to vanR-L

Browse AMR rules for vanR-L

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Validation Method: frequently observed in >1,500 strains
Drug Classes: VANCOMYCIN, Glycopeptide
Organisms: Enterococcus faecalis, Mycobacteroides abscessus complex, Rothia nasimurium
Geographic Location: China|Xinjiang
Alleles: 2
Papers: 3
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
VanR-L	Card DatabaseReference Gene Catalog	2	VANCOMYCIN	Enterococcus faecalis	-	2008	EU250284.1	ABX54691.1
vanRL

Papers3

1

Molecular characterization of Enterococcus faecalis N06-0364 with low-level vancomycin resistance harboring a novel D-Ala-D-Ser gene cluster, vanL.

PMID 18458129 · 2008

Gene Information

Gene Name: vanR-L
Allele: VanR-L
Encodes: vancomycin resistance response regulator transcription factor VanR-L
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: EU250284.1
Protein Accession: ABX54691.1
Notes: ARO:3002927

2

Molecular characterization of Enterococcus faecalis N06-0364 with low-level vancomycin resistance harboring a novel D-Ala-D-Ser gene cluster, vanL.

PMID 18458129 · 2008

Gene Information

Gene Name: vanR-L
Allele: VanR-L
Encodes: vancomycin resistance response regulator transcription factor VanR-L
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: EU250284.1
Protein Accession: ABX54691.1
Notes: ARO:3002927

3

The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.

PMID 36261788 · 2022

The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.

Gene Information

Gene Name: vanR-L
Allele: vanRL
Encodes: vancomycin resistance protein
Source Database: Reslit
Confers Resistance To: Glycopeptide
Organisms Tested In: • Mycobacteroides abscessus complex
Validation Method: frequently observed in >1,500 strains

4

Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.

PMID 40148435 · 2025

The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.

Gene Information

Gene Name: vanR-L
Allele: vanRL
Encodes: regulator of glycopeptide resistance
Source Database: Reslit
Confers Resistance To: Glycopeptide
Organisms Tested In: • Rothia nasimurium
Geographic Location: China|Xinjiang
Validation Method: genome sequencing
Sequence Accession: JAYWIX000000000|CP056080