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vanS-B

vancomycin resistance histidine kinase VanS-B

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to vanS-B

AMR Rules

Browse AMR rules for vanS-B

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Validation Method: next-generation sequencing of plasma cfDNA and matching microbiological data
Drug Classes: VANCOMYCIN, Vancomycin
Organisms: Enterococcus faecalis, Enterococcus faecium, Clostridium sp. CCRI-9842
Alleles: 4
Papers: 7
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants4

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
VanS-B	Card DatabaseReference Gene Catalog	6	VANCOMYCIN	Enterococcus faecalis +2	-	1996, 2000, 2005, 2009, 2014	AF192329.1	AAF72359.1

Papers7

Characterization of transposon Tn1549, conferring VanB-type resistance in Enterococcus spp.

PMID 10846226 · 2000

Gene Information

Gene Name: vanS-B
Allele: VanS-B
Encodes: vancomycin resistance histidine kinase VanS-B
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: AF192329.1
Protein Accession: AAF72359.1

A six amino acid deletion, partially overlapping the VanSB G2 ATP-binding motif, leads to constitutive glycopeptide resistance in VanB-type Enterococcus faecium.

PMID 14617162 · 2003

Gene Information

Gene Name: vanS-B
Allele: VanS-B-Delta
Encodes: VanB-type vancomycin resistance histidine kinase VanS-B-Delta
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AF550669.1
Protein Accession: AAQ12903.1

Characterization of a Tn5382-like transposon containing the vanB2 gene cluster in a Clostridium strain isolated from human faeces.

PMID 15731199 · 2005

Gene Information

Gene Name: vanS-B
Allele: VanS-B
Encodes: vancomycin resistance histidine kinase VanS-B
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Clostridium sp. CCRI-9842
Sequence Accession: AH014495.2
Protein Accession: AAV58812.1

Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2201, encoding erythromycin resistance and cytolysin (Hly/Bac).

PMID 19029325 · 2009

Gene Information

Gene Name: vanS-B
Allele: VanS-B
Encodes: vancomycin resistance histidine kinase VanS-B
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: AB374546.1
Protein Accession: BAH02339.1

Novel type of VanB2 teicoplanin-resistant hospital-associated Enterococcus faecium.

PMID 25059441 · 2014

Gene Information

Gene Name: vanS-B
Allele: VanS-B
Encodes: vancomycin resistance histidine kinase VanS-B
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: KF823969.1
Protein Accession: AHH83941.1

Next-generation sequencing diagnostics of bacteremia in septic patients.

PMID 27368373 · 2016

The study demonstrates the feasibility of identifying antimicrobial resistance genes through next-generation sequencing of cell-free DNA from plasma samples of septic patients, highlighting the presence of vanB, vanS B, tet1, and sat4 genes in a vancomycin-resistant Enterococcus faecium isolate.

Gene Information

Gene Name: vanS-B
Allele: vanS B
Encodes: vancomycin resistance determinant
Source Database: Reslit
Confers Resistance To: Vancomycin
Organisms Tested In: • Enterococcus faecium
Validation Method: next-generation sequencing of plasma cfDNA and matching microbiological data

Next-generation sequencing diagnostics of bacteremia in septic patients.

PMID 27368373 · 2016

Gene Information

Gene Name: vanS-B
Allele: vanS_B
Encodes: vancomycin resistance determinant
Source Database: Reslit
Confers Resistance To: Vancomycin
Organisms Tested In: • Enterococcus faecium
Validation Method: high-depth sequencing and matching to CARD database

Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583.

PMID 8631706 · 1996

Gene Information

Gene Name: vanS-B
Allele: VanS-B
Encodes: vancomycin resistance histidine kinase VanS-B
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: U35369.1
Protein Accession: AAB05623.1
Notes: ARO:3002932

Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583.

PMID 8631706 · 1996

Gene Information

Gene Name: vanS-B
Allele: VanS-B
Encodes: vancomycin resistance histidine kinase VanS-B
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: U35369.1
Protein Accession: AAB05623.1
Notes: ARO:3002932