Browse AMR Genes

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vanT-G

membrane-bound serine racemase VanT-G

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to vanT-G

Browse AMR rules for vanT-G

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Validation Method: genomic analysis
Drug Classes: VANCOMYCIN, Vancomycin, Glycopeptide
Organisms: Enterococcus faecalis, Clostridioides difficile, Porcine, Mycobacteroides abscessus complex, Escherichia coli, Staphylococcus aureus
Geographic Location: China, Europe, Europe|Asia
Alleles: 2
Papers: 8
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
VanT-G	Card DatabaseReference Gene Catalog	3	VANCOMYCIN	Enterococcus faecalis	-	2000, 2006	AF253562.2	AAF71283.1

Papers8

1

Genetic characterization of vanG, a novel vancomycin resistance locus of Enterococcus faecalis.

PMID 11036060 · 2000

Gene Information

Gene Name: vanT-G
Allele: VanT-G
Encodes: membrane-bound serine racemase VanT-G
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: AF253562.2
Protein Accession: AAF71283.1

2

VanG-type vancomycin-resistant Enterococcus faecalis strains isolated in Canada.

PMID 16723588 · 2006

Gene Information

Gene Name: vanT-G
Allele: VanT-G
Encodes: membrane-bound serine racemase VanT-G
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: AY271782.1
Protein Accession: AAQ16274.1
Notes: ARO:3002972

3

VanG-type vancomycin-resistant Enterococcus faecalis strains isolated in Canada.

PMID 16723588 · 2006

Gene Information

Gene Name: vanT-G
Allele: VanT-G
Encodes: membrane-bound serine racemase VanT-G
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: AY271782.1
Protein Accession: AAQ16274.1
Notes: ARO:3002972

4

Independent Microevolution Mediated by Mobile Genetic Elements of Individual Clostridium difficile Isolates from Clade 4 Revealed by Whole-Genome Sequencing.

PMID 30944881 · 2019

The study identified multiple antimicrobial resistance genes, including aac(6')-Ib, ermB, tetM, and catD, in Clostridium difficile isolates from clade 4, highlighting the role of mobile genetic elements in the evolution of multidrug resistance.

Gene Information

Gene Name: vanT-G
Allele: vanTG
Encodes: glycopeptide resistance determinant
Source Database: Reslit
Confers Resistance To: Vancomycin
Organisms Tested In: • Clostridioides difficile
Geographic Location: China
Validation Method: genomic analysis
Sequence Accession: NCBI BioProject: PRJNA498113

5

Early Inoculation of Microbial Suspension in Suckling Piglets Affects the Transmission of Maternal Microbiota and the Associated Antibiotic Resistance Genes.

PMID 33066283 · 2020

The study shows that early inoculation of microbial suspensions affects the transmission of maternal microbiota and the associated antibiotic resistance genes (ARGs) in piglets. Specific ARGs such as aadE_2, aphA3, ermB, lnuB, vanTG, tetQ, tnpA, mpmB, lnuC, and tetW were found to be influenced by the inoculation of microbial suspensions S1 and S2.

Gene Information

Gene Name: vanT-G
Allele: vanTG
Encodes: glycopeptide resistance gene
Source Database: Reslit
Confers Resistance To: Vancomycin
Organisms Tested In: • Porcine
Geographic Location: Europe
Validation Method: quantitative PCR

6

The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.

PMID 36261788 · 2022

The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.

Gene Information

Gene Name: vanT-G
Allele: vanTG
Encodes: vancomycin resistance protein
Source Database: Reslit
Confers Resistance To: Glycopeptide
Organisms Tested In: • Mycobacteroides abscessus complex
Validation Method: frequently observed in >1,500 strains

7

Effects of levodopa on gut bacterial antibiotic resistance in Parkinson's disease rat.

PMID 36824263 · 2023

Levodopa treatment influenced the abundance of antibiotic resistance genes in gut bacteria of Parkinson's disease rats, decreasing tetW and vanTG while increasing AAC6-Ib-Suzhou.

Gene Information

Gene Name: vanT-G
Allele: vanTG
Encodes: vancomycin resistance gene
Source Database: Reslit
Confers Resistance To: Vancomycin
Organisms Tested In: • Escherichia coli
Validation Method: metagenomic sequencing
Sequence Accession: PRJNA883557

8

Resistance phenotype and genetic features of a heterogeneous vancomycin intermediate-resistant Staphylococcus aureus strain from an immunocompromised patient.

PMID 38057692 · 2024

The study characterizes a heterogeneous vancomycin intermediate-resistant Staphylococcus aureus (hVISA) strain, identifying multiple mutations in genes associated with vancomycin resistance, including fmtB, mprF, dltA, dltD, lytM, pbp4, sceD, tagA, graR, vraG, vraR, yycH, yycI, mutL, rpoD, sigB, msaC, trpC, and atp.

Gene Information

Gene Name: vanT-G
Allele: vanTG
Encodes: glycopeptide resistance
Source Database: Reslit
Mechanism: unknown
Confers Resistance To: Vancomycin
Organisms Tested In: • Staphylococcus aureus
Geographic Location: China
Validation Method: genomic analysis
Sequence Accession: SRR24457822|SRR24457821|SRR24457820|SRR24457819

9

Differences in virulence and drug resistance between Clostridioides difficile ST37 and ST1 isolates.

PMID 40346827 · 2025

ST37 isolates exhibited higher resistance to chloramphenicol and tetracycline compared to ST1 isolates, with the presence of catQ and tetM genes in ST37 but not in ST1. ST1 isolates showed higher resistance to rifaximin, and the R505K mutation in rpoB was detected in rifaximin-resistant ST37 isolates.

Gene Information

Gene Name: vanT-G
Allele: vanTG
Encodes: serine racemase
Source Database: Reslit
Confers Resistance To: Vancomycin
Organisms Tested In: • Clostridioides difficile
Geographic Location: Europe|Asia
Validation Method: presence in ST1 isolates and absence in ST1 isolates
Sequence Accession: PRJNA1160995|ERR047167