vanTc
membrane-bound serine racemase
Overview
- Mechanism
- provides d-Ser for the synthetic pathway
- Validation Method
- cloning and MIC testing
- Drug Classes
- glycopeptides, vancomycin
- Organisms
- Enterococcus gallinarum BM4174, Escherichia coli, Enterococcus casseliflavus ATCC 25788, Enterococcus gallinarum
- Geographic Location
- France|United Kingdom
- Alleles
- 2
- Papers
- 3
- Databases
- Reslit
vanC cluster of vancomycin-resistant Enterococcus gallinarum BM4174.
The study identifies the vanC cluster in Enterococcus gallinarum BM4174, consisting of vanC-1, vanXY_C, vanT, vanR_C, and vanS_C. The genes vanC-1, vanXY_C, and vanT are necessary and sufficient for vancomycin resistance.
Gene Information
- Gene Name
- vanTc
- Allele
- VanT
- Encodes
- membrane-bound serine racemase
- Source Database
- Reslit
- Mechanism
- provides d-Ser for the synthetic pathway
- Confers Resistance To
- glycopeptides
- Organisms Tested In
- • Enterococcus gallinarum BM4174• Escherichia coli
- Validation Method
- cloning and MIC testing
- Sequence Accession
- AF162694
Biochemical and genetic characterization of the vanC-2 vancomycin resistance gene cluster of Enterococcus casseliflavus ATCC 25788.
The study characterizes the vanC-2 gene cluster in Enterococcus casseliflavus ATCC 25788, identifying genes involved in vancomycin resistance, including vanC-2, vanXY C-2, vanT C-2, vanR C-2, and vanS C-2. These genes contribute to the production of cell wall precursors that replace d-alanine with d-serine, reducing vancomycin binding.
Gene Information
- Gene Name
- vanTc
- Allele
- vanT C-2
- Encodes
- serine racemase
- Source Database
- Reslit
- Confers Resistance To
- vancomycin
- Organisms Tested In
- • Enterococcus casseliflavus ATCC 25788
- Validation Method
- cloning and enzymatic activity assays
- Sequence Accession
- AY033089
Transcriptional analysis of the vanC cluster from Enterococcus gallinarum strains with constitutive and inducible vancomycin resistance.
The study characterizes the vanC cluster in Enterococcus gallinarum strains with constitutive and inducible vancomycin resistance, identifying key genes and mutations involved in glycopeptide resistance mechanisms.
Gene Information
- Gene Name
- vanTc
- Allele
- VanT
- Encodes
- protein involved in the synthesis of d-Ser and its incorporation into the growing peptidoglycan chain
- Source Database
- Reslit
- Confers Resistance To
- vancomycin
- Organisms Tested In
- • Enterococcus gallinarum
- Geographic Location
- France|United Kingdom
- Validation Method
- transcriptional analysis and sequence comparison
- Sequence Accession
- AF162694|J01859
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