vanTr

serine racemase VanT-L catalytic subunit

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Validation Method: ARG detection using multiple tools including ABRICATE, RGI, and HMMER
Drug Classes: VANCOMYCIN, Glycopeptide
Organisms: Enterococcus faecalis, Helicobacter pylori
Geographic Location: global
Papers: 2
Databases: Card DatabaseReference Gene CatalogReslit

Papers2

Molecular characterization of Enterococcus faecalis N06-0364 with low-level vancomycin resistance harboring a novel D-Ala-D-Ser gene cluster, vanL.

PMID 18458129 · 2008

Gene Information

Gene Name: vanTr
Allele: vanTr
Encodes: serine racemase VanT-L catalytic subunit
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: EU250284.1
Protein Accession: ABX54690.1
Notes: ARO:3002974

Molecular characterization of Enterococcus faecalis N06-0364 with low-level vancomycin resistance harboring a novel D-Ala-D-Ser gene cluster, vanL.

PMID 18458129 · 2008

Gene Information

Gene Name: vanTr
Allele: vanTr
Encodes: serine racemase VanT-L catalytic subunit
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: EU250284.1
Protein Accession: ABX54690.1
Notes: ARO:3002974

Global Antimicrobial Resistance Gene Study of Helicobacter pylori: Comparison of Detection Tools, ARG and Efflux Pump Gene Analysis, Worldwide Epidemiological Distribution, and Information Related to the Antimicrobial-Resistant Phenotype.

PMID 37508214 · 2023

The study identified 42 antimicrobial resistance genes (ARG) in Helicobacter pylori, including 16 related to single antibiotic class resistance and 26 related to multidrug resistance. Key genes include hp1181, copA, msbA, vanT, vanTr, mepA, and several RND efflux pumps. These genes were validated through multiple detection tools and curation processes.

Gene Information

Gene Name: vanTr
Allele: vanTr
Encodes: glycopeptide resistance gene
Source Database: Reslit
Confers Resistance To: Glycopeptide
Organisms Tested In: • Helicobacter pylori
Geographic Location: global
Validation Method: ARG detection using multiple tools including ABRICATE, RGI, and HMMER

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