vanX-B

D-Ala-D-Ala dipeptidase VanX-B

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Drug Classes: VANCOMYCIN
Organisms: Enterococcus faecalis, Enterococcus faecium, Clostridium sp. CCRI-9842
Papers: 6
Databases: Card DatabaseReference Gene Catalog

Papers6

Characterization of transposon Tn1549, conferring VanB-type resistance in Enterococcus spp.

PMID 10846226 · 2000

Gene Information

Gene Name: vanX-B
Allele: VanX-B
Encodes: D-Ala-D-Ala dipeptidase VanX-B
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: AF192329.1
Protein Accession: AAF72364.1

High prevalence of VanB2 vancomycin-resistant Enterococcus faecium in Taiwan.

PMID 11376048 · 2001

Gene Information

Gene Name: vanX-B
Allele: VanX-B
Encodes: D-Ala-D-Ala dipeptidase VanX-B
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AF310956.2
Protein Accession: AAG34692.2

A six amino acid deletion, partially overlapping the VanSB G2 ATP-binding motif, leads to constitutive glycopeptide resistance in VanB-type Enterococcus faecium.

PMID 14617162 · 2003

Gene Information

Gene Name: vanX-B
Allele: VanX-B
Encodes: D-Ala-D-Ala dipeptidase VanX-B
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AF550667.1
Protein Accession: AAQ12895.1

Characterization of a Tn5382-like transposon containing the vanB2 gene cluster in a Clostridium strain isolated from human faeces.

PMID 15731199 · 2005

Gene Information

Gene Name: vanX-B
Allele: VanX-B
Encodes: D-Ala-D-Ala dipeptidase VanX-B
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Clostridium sp. CCRI-9842
Sequence Accession: AH014495.2
Protein Accession: AAV58817.1

Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2201, encoding erythromycin resistance and cytolysin (Hly/Bac).

PMID 19029325 · 2009