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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse GenesvanX-D

vanX-D

D-Ala-D-Ala dipeptidase VanX-D

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to vanX-D

Browse AMR rules for vanX-D

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Drug Classes: VANCOMYCIN
Organisms: Enterococcus faecium, Enterococcus raffinosus, Enterococcus gallinarum, Ruminococcus gauvreauii
Papers: 7
Databases: Card DatabaseReference Gene Catalog

Papers7

1

Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.

PMID 10368136 · 1999

Gene Information

Gene Name: vanX-D
Allele: VanX-D
Encodes: D-Ala-D-Ala dipeptidase VanX-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AF130997.1
Protein Accession: AAD42185.1

2

Molecular characterization of the vanD gene cluster and a novel insertion element in a vancomycin-resistant enterococcus isolated in Canada.

PMID 10835012 · 2000

Gene Information

Gene Name: vanX-D
Allele: VanX-D
Encodes: D-Ala-D-Ala dipeptidase VanX-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AF175293.1
Protein Accession: AAD51061.1

3

VanD-type vancomycin-resistant Enterococcus faecium 10/96A.

PMID 12499162 · 2003

Gene Information

Gene Name: vanX-D
Allele: VanX-D
Encodes: D-Ala-D-Ala dipeptidase VanX-D
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus raffinosus
Sequence Accession: AB242319.1
Protein Accession: BAE96118.1
Notes: ARO:3003070

4

VanD-type vancomycin-resistant Enterococcus faecium 10/96A.

PMID 12499162 · 2003

Gene Information

Gene Name: vanX-D
Allele: VanX-D
Encodes: D-Ala-D-Ala dipeptidase VanX-D
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus raffinosus
Sequence Accession: AB242319.1
Protein Accession: BAE96118.1
Notes: ARO:3003070

5

Enterococcus faecium N03-0072 carries a new VanD-type vancomycin resistance determinant: characterization of the VanD5 operon.

PMID 15308604 · 2004

Gene Information

Gene Name: vanX-D
Allele: VanX-D
Encodes: D-Ala-D-Ala dipeptidase VanX-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: AY489045.1
Protein Accession: AAR37061.1

6

Enterococcus gallinarum N04-0414 harbors a VanD-type vancomycin resistance operon and does not contain a D-alanine:D-alanine 2 (ddl2) gene.

PMID 16495270 · 2006

Gene Information

Gene Name: vanX-D
Allele: VanX-D
Encodes: D-Ala-D-Ala dipeptidase VanX-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus gallinarum
Sequence Accession: DQ172830.1
Protein Accession: AAZ98840.1

7

vanD and vanG-like gene clusters in a Ruminococcus species isolated from human bowel flora.

PMID 17724150 · 2007

Gene Information

Gene Name: vanX-D
Allele: VanX-D
Encodes: D-Ala-D-Ala dipeptidase VanX-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Ruminococcus gauvreauii
Sequence Accession: EF508033.1
Protein Accession: ABS72059.1

8

New combinations of mutations in VanD-Type vancomycin-resistant Enterococcus faecium, Enterococcus faecalis, and Enterococcus avium strains.

PMID 19258279 · 2009

Gene Information

Gene Name: vanX-D
Allele: VanX-D
Encodes: D-Ala-D-Ala dipeptidase VanX-D
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecium
Sequence Accession: EU999036.1
Protein Accession: ACM47288.1

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research