ResLit

vanXY-C

d,d-dipeptidase-carboxypeptidase

NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to vanXY-C
AMR Rules
Browse AMR rules for vanXY-C
Curation StatusNot Validated

Overview

Drug Classes
glycopeptides, vancomycin
Organisms
Enterococcus gallinarum BM4174, Escherichia coli, Enterococcus casseliflavus ATCC 25788 +1 more
Alleles
2
Papers
3
Allele Variants2
AllelePapersDrug ClassesOrganismsCountriesYearsStatus
vanXY_C2glycopeptides, vancomycinEnterococcus gallinarum BM4174 +2France|United Kingdom2000, 2005Not Validated
vanXY C-21vancomycinEnterococcus casseliflavus ATCC 25788-2002Not Validated
Papers3
1

vanC cluster of vancomycin-resistant Enterococcus gallinarum BM4174.

PMID 10817725 · 2000

The study identifies the vanC cluster in Enterococcus gallinarum BM4174, consisting of vanC-1, vanXY_C, vanT, vanR_C, and vanS_C. The genes vanC-1, vanXY_C, and vanT are necessary and sufficient for vancomycin resistance.

Gene Information

Gene Name
vanXY-C
Allele
vanXY_C
Encodes
d,d-dipeptidase-carboxypeptidase
Validation Method
cloning and MIC testing

Mechanism

hydrolyzes d-Ala-d-Ala and removes d-Ala from UDP-MurNAc-pentapeptide[d-Ala]

Confers Resistance To

glycopeptides

Organisms Tested In

• Enterococcus gallinarum BM4174
• Escherichia coli
2

Biochemical and genetic characterization of the vanC-2 vancomycin resistance gene cluster of Enterococcus casseliflavus ATCC 25788.

PMID 12234834 · 2002

The study characterizes the vanC-2 gene cluster in Enterococcus casseliflavus ATCC 25788, identifying genes involved in vancomycin resistance, including vanC-2, vanXY C-2, vanT C-2, vanR C-2, and vanS C-2. These genes contribute to the production of cell wall precursors that replace d-alanine with d-serine, reducing vancomycin binding.

Gene Information

Gene Name
vanXY-C
Allele
vanXY C-2
Encodes
d,d-dipeptidase-d,d-carboxypeptidase
Validation Method
cloning and enzymatic activity assays

Confers Resistance To

vancomycin

Organisms Tested In

• Enterococcus casseliflavus ATCC 25788
3

Transcriptional analysis of the vanC cluster from Enterococcus gallinarum strains with constitutive and inducible vancomycin resistance.

PMID 15728903 · 2005

The study characterizes the vanC cluster in Enterococcus gallinarum strains with constitutive and inducible vancomycin resistance, identifying key genes and mutations involved in glycopeptide resistance mechanisms.

Gene Information

Gene Name
vanXY-C
Allele
vanXY_C
Encodes
proteins involved in the hydrolysis of d-Ala-ending precursors
Validation Method
transcriptional analysis and sequence comparison

Confers Resistance To

vancomycin

Organisms Tested In

• Enterococcus gallinarum

Isolation Details

Country
France|United Kingdom
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