ResLit

vat(E)

streptogramin A resistance

NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to vat(E)
AMR Rules
Browse AMR rules for vat(E)
Curation StatusNot Validated

Overview

Drug Classes
streptogramin a, quinupristin-dalfopristin, virginiamycin
Organisms
Enterococcus faecium, Escherichia coli DB10, Enterococcus faecalis
Alleles
2
Papers
4
Allele Variants2
AllelePapersDrug ClassesOrganismsCountriesYearsStatus
Vat(E)3streptogramin a, quinupristin-dalfopristin +1Enterococcus faecium +2Europe, United States2000, 2001, 2002Not Validated
vat(E-3)1quinupristin-dalfopristinEnterococcus faeciumUnited Kingdom2001Not Validated
Papers4
1

Linkage of vat(E) and erm(B) in streptogamin-resistant Enterococcus faecium isolates from Europe.

PMID 11023445 · 2000

The study reports the first evidence of a direct physical linkage between the vat(E) and erm(B) genes in streptogramin-resistant Enterococcus faecium isolates from Europe, indicating a conserved genetic element mediating resistance to both streptogramins and macrolides.

Gene Information

Gene Name
vat(E)
Allele
Vat(E)
Encodes
streptogramin A resistance
Validation Method
cloning into E. coli DB10 and determination of MICs

Confers Resistance To

streptogramin a

Organisms Tested In

• Enterococcus faecium
• Escherichia coli DB10

Isolation Details

Country
Europe
2

Identification of vat(E-3), a novel gene encoding resistance to quinupristin-dalfopristin in a strain of Enterococcus faecium from a hospital patient in the United Kingdom.

PMID 11269234 · 2001

The study identified a novel allele, vat(E-3), which confers resistance to quinupristin-dalfopristin in a clinical isolate of Enterococcus faecium.

Gene Information

Gene Name
vat(E)
Allele
vat(E-3)
Encodes
streptogramin A acetyltransferase
Validation Method
sequencing and cloning

Confers Resistance To

quinupristin-dalfopristin

Organisms Tested In

• Enterococcus faecium

Isolation Details

Country
United Kingdom
3

Variation within the vat(E) allele of Enterococcus faecium isolates from retail poultry samples.

PMID 11557494 · 2001

The study identified five new vat(E) alleles (vat(E-4) through vat(E-8)) in quinupristin-dalfopristin-resistant Enterococcus faecium isolates from retail poultry samples.

Gene Information

Gene Name
vat(E)
Allele
Vat(E)
Encodes
streptogramin A acetyltransferase
Validation Method
DNA sequencing and PCR

Confers Resistance To

quinupristin-dalfopristin

Organisms Tested In

• Enterococcus faecium

Isolation Details

Country
United States
4

Identification of vat(E) in Enterococcus faecalis isolates from retail poultry and its transferability to Enterococcus faecium.

PMID 12435683 · 2002

The study identifies the presence of the vat(E) gene in Enterococcus faecalis isolates from retail poultry and demonstrates its transferability to Enterococcus faecium, highlighting the potential for spread of streptogramin resistance.

Gene Information

Gene Name
vat(E)
Allele
Vat(E)
Encodes
streptogramin A acetyltransferase
Validation Method
PCR and DNA sequencing

Confers Resistance To

quinupristin-dalfopristinvirginiamycin

Organisms Tested In

• Enterococcus faecalis
• Enterococcus faecium

Isolation Details

Country
United States
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