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vat(H)

streptogramin A O-acetyltransferase Vat(H)

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to vat(H)

AMR Rules

Browse AMR rules for vat(H)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Validation Method: minimum inhibitory concentration (MIC) test
Drug Classes: STREPTOGRAMIN, PRISTINAMYCIN IIA, DALFOPRISTIN, VIRGINIAMYCIN M, Streptogramin
Organisms: Enterococcus faecium, Bacteroides ovatus ELH-B2
Alleles: 3
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Vat(H)	Card DatabaseReference Gene CatalogResFinder Database	3	STREPTOGRAMIN, PRISTINAMYCIN IIA +2	Enterococcus faecium	-	2010	GQ205627.2

Papers2

Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium.

PMID 20713681 · 2010

Gene Information

Gene Name: vat(H)
Allele: Vat(H)
Encodes: streptogramin A O-acetyltransferase Vat(H)
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: STREPTOGRAMINPRISTINAMYCIN IIADALFOPRISTINVIRGINIAMYCIN M
Organisms Tested In: • Enterococcus faecium
Sequence Accession: GQ205627.2
Protein Accession: ACX92987.1
Notes: Streptogramin A acetyltransferase

Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium.

PMID 20713681 · 2010

Gene Information

Gene Name: vat(H)
Allele: Vat(H)
Encodes: streptogramin A O-acetyltransferase Vat(H)
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: STREPTOGRAMINPRISTINAMYCIN IIADALFOPRISTINVIRGINIAMYCIN M
Organisms Tested In: • Enterococcus faecium
Sequence Accession: GQ205627.2
Protein Accession: ACX92987.1
Notes: Streptogramin A acetyltransferase

Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium.

PMID 20713681 · 2010

Gene Information

Gene Name: vat(H)
Allele: Vat(H)
Encodes: streptogramin A O-acetyltransferase Vat(H)
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: STREPTOGRAMINPRISTINAMYCIN IIADALFOPRISTINVIRGINIAMYCIN M
Organisms Tested In: • Enterococcus faecium
Sequence Accession: GQ205627.2
Protein Accession: ACX92987.1
Notes: Streptogramin A acetyltransferase

Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium.

PMID 20713681 · 2010

Gene Information

Gene Name: vat(H)
Allele: vat(H)
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: PRISTINAMYCIN IIADALFOPRISTINVIRGINIAMYCIN M
Organisms Tested In: • Enterococcus faecium
Sequence Accession: GQ205627
Notes: Streptogramin A acetyltransferase

Pilot Safety Evaluation of a Novel Strain of Bacteroides ovatus.

PMID 30459813 · 2018

The study identified several antibiotic resistance genes in Bacteroides ovatus ELH-B2, including those conferring resistance to tetracycline, erythromycin, aminoglycosides, macrolides, and other antibiotics. These genes were validated through minimum inhibitory concentration (MIC) tests.

Gene Information

Gene Name: vat(H)
Allele: vatH
Encodes: Acetyl transferase
Source Database: Reslit
Mechanism: modification
Confers Resistance To: Streptogramin
Organisms Tested In: • Bacteroides ovatus ELH-B2
Validation Method: minimum inhibitory concentration (MIC) test
Sequence Accession: NZ_CP012938

PMID N/A

Gene Information

Gene Name: vat(H)
Allele: vatH
Encodes: streptogramin vat acetyltransferase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Enterococcus faecium
Sequence Accession: GQ205627.2
Protein Accession: ACX92987.1
Notes: ARO:3002845