vcaM

ABC multidrug efflux pump

Validation StatusCandidate

Overview

Mechanism: efflux pump
Validation Method: transformation of E. coli KAM32 with the gene and measurement of resistance
Drug Classes: Tetracycline, Norfloxacin, Ciprofloxacin, Erythromycin
Organisms: Escherichia coli, Vibrio cholerae
Papers: 2
Databases: Reslit

Papers2

Molecular cloning and characterization of an ABC multidrug efflux pump, VcaM, in Non-O1 Vibrio cholerae.

PMID 12878498 · 2003

The study identified and characterized the VcaM gene, an ABC multidrug efflux pump in Non-O1 Vibrio cholerae, which confers resistance to multiple antibiotics including tetracycline, fluoroquinolones, and anthracyclines.

Gene Information

Gene Name: vcaM
Allele: vcaM
Encodes: ABC multidrug efflux pump
Source Database: Reslit
Confers Resistance To: TetracyclineNorfloxacinCiprofloxacin
Organisms Tested In: • Escherichia coli
• Vibrio cholerae
Validation Method: transformation of E. coli KAM32 with the gene and measurement of resistance
Sequence Accession: AB073220

ATP-Binding Cassette Transporter VcaM from Vibrio cholerae is Dependent on the Outer Membrane Factor Family for Its Function.

PMID 29584668 · 2018

The study identifies VcaM as a multidrug ABC transporter from Vibrio cholerae that relies on the outer membrane factor TolC for its efflux function, demonstrating resistance to erythromycin.

Gene Information

Gene Name: vcaM
Allele: vcaM
Encodes: ATP-binding cassette transporter
Source Database: Reslit
Mechanism: efflux pump
Confers Resistance To: Erythromycin
Organisms Tested In: • Vibrio cholerae
• Escherichia coli
Validation Method: disk diffusion assay and Hoechst 33342 accumulation assay

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vcaM

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