Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ABC-F type ribosomal protection protein Vga(C)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Vga(C) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | VIRGINIAMYCIN M, CLINDAMYCIN +10 | Staphylococcus aureus subsp. aureus ST398 |
| Germany, Germany|United Kingdom|Ireland|France|Malta|Abu Dhabi|Hong Kong|Australia|Trinidad & Tobago|United States|Italy|Spain|Portugal|Switzerland|Canada|Middle East|USA|Asia|UK, global |
| 2006, 2009, 2011, 2023 |
| FN377602.2 |
| CAY33094.2 |
| vga(C) | ResFinder Database | 1 | CLINDAMYCIN, LINCOMYCIN +4 | Staphylococcus aureus | - | 2010 | FN806792 | - |
| vgaC | Card DatabaseReslit | 6 | Trimethoprim-sulfamethoxazole, Ciprofloxacin +4 | Klebsiella pneumoniae +6 | China, Europe | 2019, 2020, 2023 | CP033900|CP033901 | CBL58195.1 |
A new evolutionary variant of the streptogramin A resistance protein, Vga(A)LC, from Staphylococcus haemolyticus with shifted substrate specificity towards lincosamides.
A new evolutionary variant of the streptogramin A resistance protein, Vga(A)LC, from Staphylococcus haemolyticus with shifted substrate specificity towards lincosamides.
A new evolutionary variant of the streptogramin A resistance protein, Vga(A)LC, from Staphylococcus haemolyticus with shifted substrate specificity towards lincosamides.
Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
The study identifies a novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain, which confers resistance to streptogramin A antibiotics, lincosamides, and pleuromutilins.
Small plasmids carrying vga(A) or vga(C) genes mediate resistance to lincosamides, pleuromutilins and streptogramin A antibiotics in methicillin-resistant Staphylococcus aureus ST398 from swine.
A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus.
The study characterizes various methicillin-resistant Staphylococcus aureus (MRSA) clones, highlighting their antimicrobial resistance and virulence-associated markers, with a focus on SCC mec types and PVL status.
Antimicrobial Resistance in Staphylococci of Animal Origin
The paper discusses various antimicrobial resistance genes and mutations in staphylococci of animal origin, highlighting their roles in resistance to multiple antibiotics such as macrolides, lincosamides, streptogramins, oxazolidinones, and others. Key genes include erm, msr, mph, ere, lnu, vga, cfr, optrA, dfr, fus, ileS2, blaZ, aadD, ble, fosD, fosB, czrC, and qac genes, which confer resistance to specific antibiotics and are prevalent in different staphylococcal species.
Co-outbreak of multidrug resistance and a novel ST3006 Klebsiella pneumoniae in a neonatal intensive care unit: A retrospective study.
The study identified two clones of multidrug-resistant Klebsiella pneumoniae, ST37 and ST3006, in a neonatal intensive care unit. ST37 harbored multiple resistance genes, including OXA-33, TEM-1, SHV-11, and others, while ST3006 carried fewer resistance genes. Whole-genome sequencing revealed the presence of various antibiotic resistance genes and genomic islands.
Metagenomic identification of severe pneumonia pathogens in mechanically-ventilated patients: a feasibility and clinical validity study.
The study identified several AMR genes using Nanopore sequencing, including mecA, blaTEM-4, blaTEM-112, blaTEM-157, blaACT-5, oqxB, tetC, ermA, erm (33), tet38, ant(4′)-lb, tetK, tetQ, sul1, dfrA, acrF, parE, mfd, mphA, aadA5, vgaC, blaACT-5, blaACT-14, mefA, mel, tetX, tetM, isaC, and aadA5, which conferred resistance to various antibiotics such as methicillin, ticarcillin, ceftazidime, erythromycin, clindamycin, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and levofloxacin.
Metadata Analysis of mcr-1-Bearing Plasmids Inspired by the Sequencing Evidence for Horizontal Transfer of Antibiotic Resistance Genes Between Polluted River and Wild Birds.
The study identifies the mcr-1 gene as a key factor in colistin resistance in E. coli strains isolated from polluted rivers and wild birds. It also characterizes several other AMR genes including aadA1, aadA2, aph(3′)-Ia, aph(3″)-Ib, aph(4)-Ia, aph(6)-Id, tet(B), tet(D), tet(A), bla CTX–M–14, bla TEM–1, qnrS2, oqxA, oqxB, cmlA1, floR, vgaC, sul1, sul2, sul3, dfrA12, and glpT (E448K).
Fecal Klebsiella pneumoniae Carriage Is Intermittent and of High Clonal Diversity.
The study identified 25 antibiotic resistance genes in 80 Klebsiella pneumoniae isolates, primarily encoding efflux pumps and inactivating enzymes. Notably, blaSHV, emrB, emrR, marA, marR, msbA, ompK37, oqxA, oqxB, acrA, vgaC, fosA, tet(D), APH(3")-Ib, APH(6)-Id, aadA, qnrS2, rpoB2, mexF, and oprN were found to confer resistance to various antibiotics.
Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
The study identified numerous antimicrobial resistance (AMR) genes in methicillin-resistant Staphylococcus aureus (MRSA) CC398 isolates from diseased swine in Germany, including beta-lactam, tetracycline, macrolide, lincosamide, streptogramin B, phenicol, aminoglycoside, and fluoroquinolone resistance genes. These genes were often located on small transposons or plasmids, contributing to the multidrug resistance profile of the isolates.
The Intestinal Resistome of Preterm Infants Exhibited a Rich Diversity of ARGs
The study identified a rich diversity of antibiotic resistance genes (ARGs) in the intestinal microbiota of preterm infants, with beta-lactam, MLS, and tetracycline resistance being the most prevalent. Key ARGs included ermC, ermB, mecA, TEM-4, ANT(4')-Ib, isaA, vgaC, and oqxB, which were associated with various bacterial species and drug classes.
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