vgaav

putative ABC protein

Validation StatusCandidate

Overview

Validation Method: experimental validation
Drug Classes: Streptogramin a, Pleuromutilin, Lincosamide
Organisms: Staphylococcus aureus
Geographic Location: France|Portugal|Ireland|United States
Papers: 2
Databases: Reslit

Papers2

Tn5406, a new staphylococcal transposon conferring resistance to streptogramin a and related compounds including dalfopristin.

PMID 12121902 · 2002

The study characterizes Tn5406, a new staphylococcal transposon that confers resistance to streptogramin A. It identifies a variant of the vgaA gene, named vgaAv, which encodes a putative ABC protein responsible for this resistance.

Gene Information

Gene Name: vgaav
Allele: vgaAv
Encodes: putative ABC protein
Source Database: Reslit
Confers Resistance To: Streptogramin a
Organisms Tested In: • Staphylococcus aureus
Validation Method: experimental validation
Sequence Accession: AF186237

Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus.

PMID 18838584 · 2008

The study identifies VgaAv and VgaA as ABC transporter proteins that confer reduced susceptibility to pleuromutilins, lincosamides, and streptogramin A in Staphylococcus aureus.

Gene Information

Gene Name: vgaav
Allele: vgaAv
Encodes: ATP-binding cassette (ABC) transporter
Source Database: Reslit
Confers Resistance To: PleuromutilinLincosamideStreptogramin a
Organisms Tested In: • Staphylococcus aureus
Geographic Location: France|Portugal|Ireland|United States
Validation Method: cloning in S. aureus RN4220 and measurement of MICs
Sequence Accession: FJ207465

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vgaav

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