vraF

ABC transporter component

Validation StatusCandidate

Overview

Mechanism: Cell wall modification
Validation Method: E-test
Drug Classes: Vancomycin
Organisms: Staphylococcus aureus JE2, Staphylococcus aureus
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
K84E	-	single resistance variant	Staphylococcus aureus	-	Card Database	Established

Papers2

Genome-Wide Identification of Antimicrobial Intrinsic Resistance Determinants in Staphylococcus aureus.

PMID 28066345 · 2016

The study identifies multiple intrinsic resistance determinants in Staphylococcus aureus, including genes such as atpA, rpsT, vraG, and mecA, which contribute to resistance against various antimicrobial agents. These findings highlight potential targets for developing antimicrobial potentiators.

Gene Information

Gene Name: vraF
Allele: vraF
Encodes: ABC transporter component
Source Database: Reslit
Mechanism: Cell wall modification
Confers Resistance To: Vancomycin
Organisms Tested In: • Staphylococcus aureus JE2
Validation Method: E-test

Browse AMR Genes

vraF

Mutations

Gene Information