Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
two-component system sensor histidine kinase
Overview
| A314T |
| - |
| - |
| Staphylococcus aureus |
Vancomycin |
Reslit |
| Candidate |
| Y215S | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| I103T | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| G9V | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| D194N | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| A314V | - | not stated | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| M1I | - | - | Staphylococcus aureus | Daptomycin | Reslit | Candidate |
| V15G | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| G15V | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| M192I | - | enhanced catalytic efficiency | Staphylococcus aureus | VancomycinVancomycin|Daptomycin | Reslit | Candidate |
| G45R | - | mutant confers resistance | Staphylococcus aureus | Teicoplanin | Reslit | Candidate |
| V152M | - | not stated | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| S329L | - | constitutive activation of vraSR and upregulation of the genes involved in cell wall synthesis | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| F278* | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| 234fs | - | premature stop codon at 234 aa | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| G330D | - | - | Staphylococcus aureus | Nafcillin | Reslit | Candidate |
| G92V | - | - | Staphylococcus aureus | Nafcillin | Reslit | Candidate |
| V66L | - | - | Staphylococcus aureus | Nafcillin | Reslit | Candidate |
Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.
The study identifies a single amino acid substitution (S329→L) in the vraS gene as the primary mechanism for the development of heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) through the overexpression of the vraSR two-component system.
Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300.
The study identifies mutations in yvqF and vraS as critical for vancomycin resistance in a VISA strain of MRSA USA300, with yvqF acting as a negative regulator of the vraSR operon.
Unravelling the physiological roles of mazEF toxin-antitoxin system on clinical MRSA strain by CRISPR RNA-guided cytidine deaminase.
The study demonstrates that the MazF toxin contributes to increased resistance to oxacillin, daptomycin, and vancomycin in the clinical MRSA strain P-1780, likely through mechanisms involving biofilm formation and regulation of gene expression.
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