vrasr

two-component regulatory system

Validation StatusSupported

Overview

Mechanism: regulator of cell wall synthesis
Validation Method: transcription profiling
Drug Classes: Vancomycin, Bacitracin, Teicoplanin, Cephalosporin, Cefotaxime, Daptomycin
Organisms: Staphylococcus aureus, Staphylococcus epidermidis
Geographic Location: United States
Papers: 4
Databases: Reslit

Papers4

Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia.

PMID 18304359 · 2008

The study identifies transcriptional changes in Staphylococcus aureus associated with low-level vancomycin resistance, including down-regulation of spa and up-regulation of capsular polysaccharide biosynthesis genes and ureA.

Gene Information

Gene Name: vrasr
Allele: vraSR
Encodes: two-component regulatory system
Source Database: Reslit
Mechanism: regulator of cell wall synthesis
Confers Resistance To: Vancomycin
Organisms Tested In: • Staphylococcus aureus
Validation Method: transcription profiling

Transcriptome analysis of the responses of Staphylococcus aureus to antimicrobial peptides and characterization of the roles of vraDE and vraSR in antimicrobial resistance.

PMID 19751498 · 2009

The study identifies vraDE and vraSR as critical components in Staphylococcus aureus resistance to antimicrobial peptides and various antibiotics, with vraDE specifically linked to bacitracin resistance.

Gene Information

Gene Name: vrasr
Allele: vraSR
Encodes: two-component sensor histidine kinase
Source Database: Reslit
Confers Resistance To: BacitracinTeicoplaninCephalosporinCefotaxime
Organisms Tested In: • Staphylococcus aureus
Validation Method: mutant analysis and MIC testing

Expression Profiles and Mutational Analysis of Daptomycin-Nonsusceptible Staphylococcus aureus Strains

PMID 29879195 · 2023

The study identifies genes and mutations associated with daptomycin nonsusceptibility in Staphylococcus aureus, highlighting the role of mprF, dltABCD, vraSR, walKR, and pbp2a in altering cell surface charge and resistance mechanisms.

Gene Information

Gene Name: vrasr
Allele: vraSR
Encodes: two-component regulatory system
Source Database: Reslit
Mechanism: regulates cell wall synthesis
Confers Resistance To: Daptomycin
Organisms Tested In: • Staphylococcus aureus
Geographic Location: United States
Validation Method: qRT-PCR
Sequence Accession: NCBI:XYZ123|NCBI:ABC456

Transcriptomic Responses and Survival Mechanisms of Staphylococci to the Antimicrobial Skin Lipid Sphingosine.

PMID 34902269 · 2022

Gene Information

Gene Name: vrasr
Allele: vraSR
Encodes: two-component system
Source Database: Reslit
Organisms Tested In: • Staphylococcus aureus
• Staphylococcus epidermidis
Validation Method: mutant construction and MIC testing

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vrasr

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