waaF

protein required for LPS core oligosaccharide biosynthesis

Validation StatusCandidate

Overview

Mechanism: resistance to antimicrobial chemokines CCL25 and CCL28
Validation Method: transposon mutagenesis and polymyxin B resistance assay
Drug Classes: Polymyxin b
Organisms: Burkholderia pseudomallei, Yersinia pseudotuberculosis
Papers: 2
Databases: Reslit

Papers2

Extreme antimicrobial Peptide and polymyxin B resistance in the genus burkholderia.

PMID 21811491 · 2011

The study identifies several genes and mechanisms involved in extreme antimicrobial peptide and polymyxin B resistance in Burkholderia species, including waaF, ugd BCAL2946, ugd BCAM0855, rpoE, norM, zmpA, zmpB, mucD, and ispH.

Gene Information

Gene Name: waaF
Allele: waaF
Encodes: protein required for LPS core oligosaccharide biosynthesis
Source Database: Reslit
Confers Resistance To: Polymyxin b
Organisms Tested In: • Burkholderia pseudomallei
Validation Method: transposon mutagenesis and polymyxin B resistance assay

Lipopolysaccharide Biosynthesis Genes of Yersinia pseudotuberculosis Promote Resistance to Antimicrobial Chemokines.

PMID 27275606 · 2016

The study identifies the hldD/waaF/waaC operon as crucial for Yersinia pseudotuberculosis resistance to antimicrobial chemokines CCL25 and CCL28, highlighting the role of lipopolysaccharide biosynthesis in modulating AMC binding and susceptibility.

Gene Information

Gene Name: waaF
Allele: waaF
Encodes: heptosyltransferase
Source Database: Reslit
Mechanism: resistance to antimicrobial chemokines CCL25 and CCL28
Organisms Tested In: • Yersinia pseudotuberculosis
Validation Method: transposon mutagenesis and AMC binding assays

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waaF

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